2882-18-0

Basic information

• Product Name: 2(1H)-Pyrazinone, 3-phenyl-
• Synonyms: 2(1H)-Pyrazinone, 3-phenyl-;2-hydroxy-3-phenylpyrazine;3-Phenyl-1H-pyrazin-2-one;3-Phenyl-2(1H)-pyrazinone;3-Phenylpyrazin-2(1H)-one;Cefaclor EP Impurity F
• CAS NO: 2882-18-0
• Molecular Formula: C₁₀H₈N₂O
• Molecular Weight: 172.18
• Product Categories: Aromatics, Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 2882-18-0.mol
• Article Data: 8

Chemical Properties

• Melting Point: 172-174℃
• Boiling Point: 457.4 °C at 760 mmHg
• Flash Point: 230.5 °C
• Appearance: /
• Density: 1.20
• Vapor Pressure: 5.48E-09mmHg at 25°C
• Refractive Index: 1.623
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 11.26±0.40(Predicted)
• CAS DataBase Reference: 2(1H)-Pyrazinone, 3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyrazinone, 3-phenyl-(2882-18-0)
• EPA Substance Registry System: 2(1H)-Pyrazinone, 3-phenyl-(2882-18-0)

Safety Data

• Hazardous Substances Data: 2882-18-0(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 2882-18-0 differently. You can refer to the following data:
1. 2-Hydroxy-3-phenylpyrazine is a degradation product of Cefaclor (C235250), a second-generation cephalosporin antibiotic.
2. 2-Hydroxy-3-phenylpyrazine (Cefaclor EP Impurity F) is a degradation product of Cefaclor (C235250), a second-generation cephalosporin antibiotic.

InChI:InChI=1/C10H8N2O/c13-10-9(11-6-7-12-10)8-4-2-1-3-5-8/h1-7H,(H,12,13)

Upstream product

• 6270-63-9 pyrazin-2(1H)-one 
• 100-34-5 benzene diazonium chloride 
• 64753-81-7 cefaclor 
• 160315-09-3 2-acetoxy-3-phenylpyrazine 
• 41270-65-9 2-chloro-3-phenylpyrazine 
• 98-80-6 phenylboronic acid 
• 62-53-3 aniline 
• 369-57-3 benzenediazonium tetrafluoroborate 
• 6270-63-9 pyrazin-2-ol 
• 58861-94-2 2-phenylpyrazine 4-oxide 
• 58861-89-5 2-phenylpyrazine N⁽¹⁾-oxide 
• 58861-87-3 2-chloro-3-phenyl-pyrazine 4-oxide 
• 29460-97-7 2-phenylpyrazine 
• 1074-12-0 phenylglyoxal hydrate 

Downstream Products

• 41270-65-9 2-chloro-3-phenylpyrazine 
• 98993-82-9 5-bromo-3-phenyl-1H-pyrazin-2-one 
• 2882-17-9 2-bromo-3-phenylpyrazine 
• 17705-33-8 3-phenylpyrazine-2-thiol 
• 243472-81-3 2-phenyl-3-trimethylsilanyloxy-pyrazine 
• 5368-28-5 2-phenyl-3-keto-piperazine 
• 74134-66-0 5-chloro-3,6-diphenyl-1H-pyrazin-2-one 
• 98948-89-1 3-bromo-5-chloro-6-phenyl-1H-pyrazin-2-one 
• 100142-71-0 2,5-dimethoxy-3-phenyl-pyrazine 
• 99984-69-7 3-methoxy-2-phenyl-pyrazine-1-oxide 
• 860410-57-7 2-chloro-5-methoxy-3-phenylpyrazine 
• 104092-52-6 5-chloro-2-methoxy-3-phenyl-pyrazine 
• 102653-50-9 5-chloro-3-phenyl-2(1H)-pyrazinone 
• 64163-16-2 5-chloro-6-phenyl-1H-pyrazin-2-one 

Relevant articles and documents

Isolation and identification of a fluorophore from ampicillin degradation

A fluorescent impurity in ampicillin has been isolated and identified as 2-hydroxy-3-phenyl-pyrazine. The product is formed under acidic conditions similar to those employed in some fluorometric assay procedures. The mechanism of the reaction is proposed to involve cyclization by condensation of the penilloaldehyde of ampicillin. The structure was confirmed by independent synthesis.

Electrochemical Cross-Coupling of C(sp2)?H with Aryldiazonium Salts via a Paired Electrolysis: an Alternative to Visible Light Photoredox-Based Approach

Photoredox-based C?H bond functionalization constitutes one of the most powerful and atom-economical approaches to organic syntheses. During this type of reaction, single electron transfer takes place between the photocatalyst (PC) and redox- active substrates. Electrosynthesis also involves electron transfer between substrates and electrodes. In this paper, we focus upon electrochemical cross-coupling of C(sp2)?H with aryldiazonium salts and have developed an efficient electrochemical approach to the Minisci-type arylation reaction. The constant current paired electrosynthesis proceeds in a simple undivided cell without external supporting electrolyte, features a wide range of substrates and is easy to scale-up. These results demonstrate that photoredox-based cross-coupling of C(sp2)?H with aryldiazonium salts can also proceed successfully under paired electrolysis conditions, thereby contributing to understanding of the parallels between photosynthesis and electrosynthesis. (Figure presented.).

Synthesis and Biological activity of kappa opioid receptor agonists. Part 2: Preparation of 3-aryl-2-pyridone analogues generated by solution- and solid-phase parallel synthesis methods

New analogues of the previously described 3-aryl pyridone KOR agonists have been synthesised by parallel synthetic methods, both in solution- and with solid-phase chemistry, making use of the well known and versatile Mitsunobu, Suzuki and Buchwald reactions. Opioid receptor binding data for the compounds produced is reported.