28987-59-9

Basic information

• Product Name: 2-CHLORO-4-METHOXYNITROBENZENE
• Synonyms: Anisole, 3-chloro-4-nitro-
• CAS NO: 28987-59-9
• Molecular Formula: C₇H₆ClNO₃
• Molecular Weight: 187.58
• Mol File: 28987-59-9.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 302.5 °C at 760 mmHg
• Flash Point: 136.7 °C
• Appearance: /
• Density: 1.366
• Vapor Pressure: 0.00177mmHg at 25°C
• Refractive Index: 1.559
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-CHLORO-4-METHOXYNITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-METHOXYNITROBENZENE(28987-59-9)
• EPA Substance Registry System: 2-CHLORO-4-METHOXYNITROBENZENE(28987-59-9)

Safety Data

• Hazardous Substances Data: 28987-59-9(Hazardous Substances Data)

Usage

General Description

2-Chloro-4-methoxynitrobenzene is a chemical compound with the molecular formula C7H6ClNO3. It is a pale yellow crystalline solid that is used as an intermediate in the synthesis of pharmaceuticals and agricultural chemicals. 2-Chloro-4-methoxynitrobenzene is primarily used in the production of dyes, pigments, and other chemical products. It is important to handle this chemical with care, as it is toxic if ingested and can cause irritation if it comes into contact with the skin or eyes. Additionally, it may release toxic fumes if heated to decomposition. 2-Chloro-4-methoxynitrobenzene should be stored and handled in accordance with proper safety guidelines and regulations.

InChI:InChI=1/C7H6ClNO3/c1-12-5-2-3-7(9(10)11)6(8)4-5/h2-4H,1H3

Upstream product

• 491-11-2 3-chloro-4-nitrophenol 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 2845-89-8 1-chloro-3-methoxy-benzene 
• 108-43-0 3-monochlorophenol 
• 40140-91-8 3-chloro-4-nitrosophenol 
• 615-58-7 2,4-dibromophenol 
• 1882-69-5 5-methoxy-2-nitro-benzoic acid 
• 541-73-1 1,3-Dichlorobenzene 
• 611-06-3 2,4-dichloronitrobenzene 
• 124-41-4 sodium methylate 
• 2106-50-5 2-chloro-4-fluoro-1-nitrobenzene 

Downstream Products

• 28093-74-5 N-cyclohexyl-5-methoxy-2-nitro-aniline 
• 107518-77-4 5-methoxy-2-nitro-N-(2-N-phthalimidoethyl)aniline 
• 90005-98-4 (5-methoxy-2-nitrophenyl)(methyl)sulfane 
• 860734-04-9 bis-(5-methoxy-2-nitro-phenyl)-sulfide 
• 69397-93-9 N-methyl-5-methoxy-2-nitroaniline 
• 854651-57-3 N,N-diethyl-N'-(5-methoxy-2-nitro-phenyl)-propanediyldiamine 
• 872807-72-2 N⁴,N⁴-diethyl-N¹-(5-methoxy-2-nitro-phenyl)-1-methyl-butanediyldiamine 
• 35350-40-4 bis-(5-methoxy-2-nitro-phenyl)-disulfide 
• 704-14-3 3-methoxy-6-nitro-phenol 
• 16133-49-6 5-methoxy-2-nitroaniline 
• 6480-66-6 2,6-dichloro-4-methoxyaniline 
• 875241-65-9 4-methoxy-1-nitro-2-phenoxybenzene 
• 29242-84-0 2-chloro-4-methoxyaniline 
• 17800-17-8 2-Amino-4-chlor-5'-methoxy-2'-nitro-diphenylsulfid 

Relevant articles and documents

Quinoxaline compound, preparation method and application of quinoxaline compound in medicine

The invention provides a quinoxaline compound, a preparation method and application of the quinoxaline compound in medicine, and particularly relates to a quinoxaline compound with PAR4 antagonistic activity, a preparation method of the quinoxaline compound, a pharmaceutical composition containing the quinoxaline compound and application of the quinoxaline compound. Specifically, the invention provides a compound shown as a general formula I and/or II or a tautomer or pharmaceutically acceptable salt thereof, a preparation method of the compound, and application of the compound or the tautomer or the pharmaceutically acceptable salt in medicines for preventing and/or treating thromboembolic diseases.

Inexpensive NaX (X = I, Br, Cl) as a halogen donor in the practical Ag/Cu-mediated decarboxylative halogenation of aryl carboxylic acids under aerobic conditions

Versatile and practical Ag/Cu-mediated decarboxylative halogenation between readily available aryl carboxylic acids and abundant NaX (X = I, Br, Cl) has been achieved under aerobic conditions in moderate to good yields. The halodecarboxylation is shown to be an effective strategy for S-containing heteroaromatic carboxylic acid and benzoic acids with nitro, chloro and methoxyl substituents at the ortho position. A gram-scale reaction and a three-step procedure to synthesize iniparib have been performed to evaluate the practicality of this protocol. A preliminary mechanistic investigation indicates that Cu plays a vital role and a radical pathway is involved in the transformation.

Synthetic method of aryl halide taking aryl carboxylic acid as raw material

A synthetic method of an aryl halide taking aryl carboxylic acid as a raw material is characterized in that a corresponding aryl halide is formed by carrying out substitution reaction on an aryl carboxylic acid compound and haloid salt MX in an organic solvent under the condition that oxygen, a silver catalyst, a copper additive and a bidentate nitrogen ligand exist, wherein M in MX represents alkali metal or alkaline earth metal, and X represents F, Cl, Br or I. Compared with a conventional aryl halide synthetic method, the synthetic method disclosed by the invention has the obvious advantages that reaction raw materials (comprising aryl carboxylic acid and MX) are cheap and easy to obtain, the using amount of a metal catalyst is small, pollution to the environment when the oxygen is used as an oxidant is the smallest, good tolerance to various functional groups on an aromatic ring is obtained, the yield is high, and the like. The synthetic method disclosed by the invention can be widely applied to synthesis in the fields of medicine, materials, natural products and the like in industry and academia.