2972-75-0

Basic information

• Product Name: Propanedinitrile, [(2,5-dimethoxyphenyl)methylene]-
• CAS NO: 2972-75-0
• Molecular Formula: C12H10N2O2
• Molecular Weight: 214.224
• Mol File: 2972-75-0.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Propanedinitrile, [(2,5-dimethoxyphenyl)methylene]-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedinitrile, [(2,5-dimethoxyphenyl)methylene]-(2972-75-0)
• EPA Substance Registry System: Propanedinitrile, [(2,5-dimethoxyphenyl)methylene]-(2972-75-0)

Safety Data

• Hazardous Substances Data: 2972-75-0(Hazardous Substances Data)

Upstream product

• 672-13-9 2-hydroxy-5-methoxybenzaldehyde 
• 93-02-7 2,5-dimethoxybenzaldehyde 
• 109-77-3 malononitrile 

Downstream Products

• 130715-55-8 2-Amino-4-(2,5-dimethoxy-phenyl)-5-hydroxy-4H-chromene-3-carbonitrile 
• 93-02-7 2,5-dimethoxybenzaldehyde 
• 132814-01-8 6-amino-4-(2,5-dimethoxyphenyl)-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile 
• 1006703-14-5 C₂₀H₂₁N₃O₃ 
• 1314080-75-5 (S)-diethyl 5-amino-4-cyano-3-(2,5-dimethoxyphenyl)-1-formyl-1H-pyrrole-2,2(3H)-dicarboxylate 
• 296263-62-2 C₁₅H₁₃N₅O₃ 
• 316360-38-0 6-amino-3-propyl-4-(thiophen-2-yl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile 

Relevant articles and documents

Synthesis, molecular docking, and in silico ADME prediction of some fused pyrazolo[1,5-a]pyrimidine and pyrazole derivatives as potential antimicrobial agents

Twenty compounds of pyrazolo[1,5-a]pyrimidines 14a–j and pyrazole derivatives as Schiff bases 16a–j have been synthesized by the reaction of 5-amino-pyrazole derivatives 9a, b with 2-(arylidene)malononitriles 10a–e or various aldehydes 15a–e, respectively

New quinoline- and isoquinoline-based multicomponent methods for the synthesis of 1,1(3,3)-dicyanotetrahydrobenzoindolizines

Convenient multicomponent methods for the synthesis of benzannulated dihydroindolizines based on quinoline or isoquinoline, malononitrile, aromatic aldehydes and α-halomethylcarbonyl compounds were developed. Several alternative protocols of using the reactants were studied, starting with separate generation of two most probable intermediates and ending with the four-component condensation of all reactants. The scope of applicability of these methods was found, depending on the initial compounds used. The reaction is highly stereoselective with predominant formation of one of the possible isomers.

Synthesis of Novel 4 H-Chromenes Containing a Pyrimidine-2-Thione Function in the Presence of Fe3O4 Magnetic Nanoparticles and Study of Their Antioxidant Activity

The aim of the present work was to search for identification of novel reactive oxygen species (ROS) scavengers by testing new fused chromenopyrimidinethiones, which was synthesized using Fe3O4 nanoparticles. The new compounds were also tested for their cytotoxic activity. The obtained results showed that the incorporated pyrimidinethione moiety significantly increase antioxidant activity. In conclusion, the study of the pharmacological properties of the new chromenopyrimidinethiones allowed establishing new structure-activity relationships for splitting antioxidant and cytotoxic activity of these compounds.