3019-04-3Relevant articles and documents
THE SOLUTION-STATE CONFORMATIONS OF IODOACETONE AND ω-IODOACETOPHENONE
Lumbroso, H.,Liegeois, Ch.,Guerrero, S. A.,Olivato, P. R.,Hase, Y.
, p. 141 - 149 (1987)
A comparison of the experimental dipole moments of iodoacetone and ω-iodoacetophenone in n-hexane, carbon tetrachloride and benzene solution at 30.0 deg C with the values calculated (with inclusion of induced moments through space) for both cis and gauche conformers gives estimates of their (cis):(gauche) conformational ratios in these media.Molecular mechanics calculations show that the cis conformers of iodoacetone and ω-iodoacetophenone are nearly uniplanar, whereas the gauche-conformers of these compounds are characterized by (O=C-CH2-I) dihedral angles of 100.5 and 98.5 deg, respectively.
A New Chemical Oscillator in a Novel Open Reactor: The ClO2-I2-Acetone System in a Membrane Fed Stirred Tank Reactor
Marlovits, Gabor,Wittmann, Maria,Noszticzius, Zoltan,Gaspar, Vilmos
, p. 5359 - 5364 (1995)
The title reaction was carried out in a new type of semibatch reactor, where iodine or both iodine and chlorine dioxide are fed to the stirred bulk of the reactor through thin and selective silicon rubber membranes.For model calculations the iodine inflow rate and the pseudo-first-order rate constant of the iodide production from iodine were determined experimentally.All other reactions and rate constants were taken from the literature.The period and the duration of the experimentally found and theoretically predicted oscillations agree rather well.An exact electrochemical interpretation of the amplitude of the electrode potential oscillations requires further research.
-
Solly et al.
, p. 4653 (1970)
-
1,2-Dibromoethane and KI mediated α-acyloxylation of ketones with carboxylic acids
Wang, Xujie,Li, Gangsheng,Yang, Yanan,Jiang, Jianshuang,Feng, Ziming,Zhang, Peicheng
supporting information, p. 711 - 714 (2019/09/30)
The 1,2-dibromoethane- and KI-mediated α-acyloxylation of ketones is reported in moderate to good yield without the use of transition metals and strong oxidants. Various acids are well tolerated with wide functional group compatibility. An 1,2-dibromoethane- and KI-catalysed reaction mechanism is proposed based on the results of control experiments.
Synthesis and antiviral evaluation of 4′-(1,2,3-triazol-1-yl) thymidines
Vernekar, Sanjeev Kumar V.,Qiu, Li,Zacharias, Jeana,Geraghty, Robert J.,Wang, Zhengqiang
supporting information, p. 603 - 608 (2014/05/06)
Non-obligate chain terminating nucleosides with a linear substituent (azido or ethynyl group) at the 4′ position represent an important class of compounds in antiviral discovery, particularly against hepatitis C virus (HCV) and human immunodeficiency virus (HIV). We have previously shown that 3′-azidothymidine (AZT)-derived 1,2,3-triazoles can be potent inhibitors of HIV-1. To gauge the medicinal chemistry impact of functionalizing the 4′-linear substituent and possibly generate novel antiviral nucleoside scaffolds, we have explored azide-alkyne cycloaddition reactions with 4′-azidothymidine (ADRT). The Ru-mediated reaction failed and the Cu-catalyzed variant generated 1,2,3-triazoles (9a-y) with only modest yields and efficiencies, indicating a substantial steric barrier around the 4′-azido group. Antiviral screening identified a few triazole analogues moderately active against HIV-1 (18-62% inhibition at 10 μM) and/or influenza A virus (15-50% inhibition at 10 μM), and none active against West Nile virus (WNV) or HCV. These results suggest that the linear 4′ azido group of ADRT may be essential for target binding and that its chemical manipulation could largely compromise antiviral potency. This journal is the Partner Organisations 2014.
