30427-93-1

Basic information

• Product Name: 1-BROMO-4-(P-TOLYLOXY)BENZENE
• Synonyms: 1-BROMO-4-(P-TOLYLOXY)BENZENE;1-Bromo-4-(4-methylphenoxy)benzene;1-(4-bromophenoxy)-4-methylbenzene
• CAS NO: 30427-93-1
• Molecular Formula: C₁₃H₁₁BrO
• Molecular Weight: 263.12984
• Mol File: 30427-93-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 314.837°C at 760 mmHg
• Flash Point: 124.131°C
• Appearance: /
• Density: 1.367g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: 1-BROMO-4-(P-TOLYLOXY)BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BROMO-4-(P-TOLYLOXY)BENZENE(30427-93-1)
• EPA Substance Registry System: 1-BROMO-4-(P-TOLYLOXY)BENZENE(30427-93-1)

Safety Data

• Hazardous Substances Data: 30427-93-1(Hazardous Substances Data)

Usage

General Description

1-Bromo-4-(p-tolyloxy)benzene, also known as 4-Bromophenyl p-tolyl ether, is an organic compound with the chemical formula C14H13BrO. It is a white crystalline solid that is used as an intermediate in the production of pharmaceuticals, dyes, and other organic compounds. It is commonly used in organic synthesis, particularly in the formation of aromatic compounds. The compound is a benzene derivative with a bromine atom and a p-tolyl group attached to the benzene ring. It is an important building block in the synthesis of various organic compounds and can undergo various chemical reactions to yield different products. Additionally, 1-Bromo-4-(p-tolyloxy)benzene is also used as a reagent in the field of organic chemistry and as a research chemical.

InChI:InChI=1/C13H11BrO/c1-10-2-6-12(7-3-10)15-13-8-4-11(14)5-9-13/h2-9H,1H3

Upstream product

• 106-37-6 1.4-dibromobenzene 
• 1192-96-7 potassium p-cresolate 
• 1706-12-3 4-phenoxytoluene 
• 7726-95-6 bromine 
• 64-19-7 acetic acid 
• 106-44-5 p-cresol 
• 106-41-2 4-bromo-phenol 
• 5720-05-8 4-methylphenylboronic acid 
• 106-38-7 para-bromotoluene 
• 624-31-7 4-tolyl iodide 
• 2050-47-7 4,4'-dibromodiphenyl ether 
• 74-88-4 methyl iodide 

Downstream Products

• 1029438-40-1 C₁₃H₁₃BO₃ 
• 46919-43-1 4-(p-Tolyloxy)-benzolphosphonsaeure 

Relevant articles and documents

Cu(I)-PNF, an organic-based nanocatalyst, catalyzed C-O and C-S cross-coupling reactions

Peptide nanofiber has been prepared via a self-assembly protocol and decorated with Cu(I) to prepare a nanostructural catalyst. The catalytic activity of this prepared nanomaterial (Cu(I)-PNF) was examined in C-O and C-S cross-coupling reactions. Compared with conventional copper-ligand catalytic systems, CuNP-PNF has unique advantages such as water solubility, high efficiency, and low cost, which makes it a highly efficient and beneficial catalyst to reuse in cross-coupling reactions.

Copper mediated formation of carbon-heteroatom bonds using organoboron reagents and ultrasound

This report summarizes research efforts focused on copper acetate mediated reactions to form new carbon-heteroatom bonds using organoboron reagents under ultrasound irradiation. The method involves the application of ultrasound irradiation to the Chan-Evans-Lam reaction to achieve O-arylation of phenols, N-arylation of anilines and indoles, and S-arylation of thiols. Ultrasound irradiation was found to decrease reaction times from 72 hours to 4 hours while improving the product yields an average of 20%.1 Representative C-O, C-N, and C-S coupling reactions were successfully scaled-up from the milligram to gram levels while maintaining good product yields offering potential applications in industrial processes.

2,2′-Dimethoxy-1,1′-binaphthyl-3,3′-diboronic acid, a versatile intermediate in the synthesis of 3,3′-diaryl substituted binaphthyl derivatives

2,2′-Dimethoxy-1,1′-binaphthyl-3,3′-diboronic acid was prepared in 48% yield from 2,2′-dimethoxy-1,1′-binaphthyl and used as a key intermediate in Suzuki cross-coupling reactions to yield various 2,2′,3,3′-symmetrically substituted binaphthyl derivatives