305347-21-1 Usage
Description
(1-BUTYL-1H-BENZIMIDAZOL-2-YL)METHANOL is a chemical compound that features a butyl group attached to a benzimidazole ring, which is connected to a methanol molecule. (1-BUTYL-1H-BENZIMIDAZOL-2-YL)METHANOL has potential applications in various fields, particularly in pharmaceuticals, due to the known antiparasitic, antiviral, and anticancer properties of benzimidazole compounds. The presence of the methanol group also suggests its potential use as a solvent or in chemical reactions.
Used in Pharmaceutical Industry:
(1-BUTYL-1H-BENZIMIDAZOL-2-YL)METHANOL is used as a pharmaceutical compound for its potential antiparasitic, antiviral, and anticancer properties, which are attributed to the benzimidazole structure.
Used in Chemical Synthesis:
(1-BUTYL-1H-BENZIMIDAZOL-2-YL)METHANOL is used as a solvent or in chemical reactions due to the presence of the methanol group, which may facilitate various chemical processes.
Further research and testing are required to fully understand the potential uses and properties of (1-BUTYL-1H-BENZIMIDAZOL-2-YL)METHANOL, as its applications and effectiveness in different fields are still under investigation.
Check Digit Verification of cas no
The CAS Registry Mumber 305347-21-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,5,3,4 and 7 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 305347-21:
(8*3)+(7*0)+(6*5)+(5*3)+(4*4)+(3*7)+(2*2)+(1*1)=111
111 % 10 = 1
So 305347-21-1 is a valid CAS Registry Number.
305347-21-1Relevant articles and documents
Discovery of benzimidazole derivatives as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity
Ma, Zonghui,Jiang, Ling,Li, Bingyan,Liang, Dailin,Feng, Yu,Liu, Li,Jiang, Cheng
, (2021/08/17)
Aldehyde dehydrogenase 1A1 (ALDH1A1) plays vital physiological and toxicological functions in many areas, such as CNS, inflammation, metabolic disorders, and cancers. Overexpression of ALDH1A1 has been disclosed to play an important role in obesity, diabetes and other diseases, indicating the potential need for the identification and development of small molecule ALDH1A1 inhibitors. Herein, a series of benzimidazole derivatives was designed, synthesized and evaluated. Among them, compounds 21, 27, 29, 61 and 65 exhibited excellent inhibitory activity against ALDH1A1 with IC50 values in the low micromolar range and high selectivity over ALDH1A2, ALDH1A3, ALDH2 and ALDH3A1. Moreover, an in vitro study demonstrated that all five compounds effectively improved glucose consumption in HepG2 cells, of which, 61 and 65 at 10 μM produced nearly equal glucose consumption with positive control Metformin (Met) at 1 mM. Furthermore, 61 and 65 showed desirable metabolic stability in human liver microsomes. All these results suggest that 61 and 65 are suitable for further studies.
