3083-88-3

Basic information

• Product Name: 1-butyl-3-phenylurea
• Synonyms: 1-Butyl-3-phenylurea; Urea, N-butyl-N'-phenyl-
• CAS NO: 3083-88-3
• Molecular Formula: C₁₁H₁₆N₂O
• Molecular Weight: 192.2575
• Mol File: 3083-88-3.mol
• Article Data: 41

Chemical Properties

• Boiling Point: 284.9°C at 760 mmHg
• Flash Point: 106.9°C
• Density: 1.063g/cm³
• Vapor Pressure: 0.00289mmHg at 25°C
• Refractive Index: 1.554
• CAS DataBase Reference: 1-butyl-3-phenylurea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-butyl-3-phenylurea(3083-88-3)
• EPA Substance Registry System: 1-butyl-3-phenylurea(3083-88-3)

Safety Data

• Hazardous Substances Data: 3083-88-3(Hazardous Substances Data)

Usage

Physical form

White to off-white crystalline powder

Solubility

Soluble in organic solvents

Uses

Metal chelator in analytical chemistry, intermediate in the synthesis of pharmaceuticals

Health hazards

Potential irritant to the skin, eyes, and respiratory system, may cause skin sensitization with prolonged or repeated exposure

Handling precautions

Handle with care, wear appropriate personal protective equipment.

Upstream product

• 69858-52-2 N-but-3-enyl-N'-phenyl-urea 
• 108-86-1 bromobenzene 
• 201230-82-2 carbon monoxide 
• 109-73-9 N-butylamine 
• 591-50-4 iodobenzene 
• 199620-14-9 chromium⁽⁰⁾ hexacarbonyl 
• 3422-02-4 N-(benzyloxycarbonyl)aniline 
• 98-88-4 benzoyl chloride 
• 124-38-9 carbon dioxide 
• 62-53-3 aniline 
• 42864-21-1 2,2,2-trichloroethyl-N-phenyl carbamate 
• 622-37-7 Phenyl azide 
• 82743-97-3 N-butyl-N'-hydroxybenzimidamide 
• 698-16-8 benzohydroximoyl chloride 

Downstream Products

• 6333-41-1 N-butyl-N’-(4-chlorophenyl)urea 
• 67159-94-8 1-butyl-3-phenyl-[1,3,5]triazinane-2,4,6-trione 
• 100709-32-8 5,5-dibromo-1-butyl-3-phenyl-barbituric acid 
• 38429-77-5 N-butyl-N'-(4-sulfamoyl-phenyl)-urea 
• 658061-59-7 5,6-diamino-3-butyl-1-phenyl-1H-pyrimidine-2,4-dione 
• 14994-77-5 butyl-carbamic acid 
• 62-53-3 aniline 
• 109-73-9 N-butylamine 
• 21848-95-3 N-phenyl-N'-(n-butyl)carbodiimide 
• 99857-81-5 N-butylcarbamoyl-sulfanilyl chloride 
• 890573-84-9 N-(p-iodophenyl)-N′-butylurea 

Relevant articles and documents

Lanthanum(III) Trifluoromethanesulfonate Catalyzed Direct Synthesis of Ureas from N-Benzyloxycarbonyl-, N -Allyloxycarbonyl-, and N -2,2,2-Trichloroethoxycarbonyl-Protected Amines

A novel lanthanum triflate mediated conversion of N -benzyloxycarbonyl-, N -allyloxycarbonyl-, and N -trichloroethoxycarbonyl-protected amines into nonsymmetric ureas was discovered. In this study, lanthanum triflate was found to be an effective catalyst for preparing various nonsymmetric ureas from protected amines. A variety of protected aromatic and aliphatic carbamates reacted readily with various amines in the presence of lanthanum triflate to generate the desired ureas in high yields. This result demonstrated that this novel lanthanum triflate catalyzed preparation of ureas from Cbz, Alloc, and Troc carbamates can be employed for the formation of various urea structures.

A Fe3O4?SiO2/Schiff Base/Pd Complex as an Efficient Heterogeneous and Recyclable Nanocatalyst for One-Pot Domino Synthesis of Carbamates and Unsymmetrical Ureas

A palladium-catalyzed domino method for the direct synthesis of carbamates and ureas has been developed by using readily available and economical starting materials (aryl halide, carbon monoxide, sodium azide, amines and alcohols) in a one-pot approach. The domino process underwent carbonylation, Curtius rearrangement, and nucleophilic addition. This protocol provides a step-economical and highly efficient reaction to access the wide range of valuable carbamates, symmetrical and unsymmetrical ureas with high yields under remarkable mild reaction conditions that are important factors in pharmaceutical science, biochemistry and agricultural industries. Furthermore, the magnetically recoverable nanocatalyst (Fe3O4?SiO2/Pd(II)) can be conveniently and swiftly recycled using external magnet and reused at least for seven times without noticeable loss of its catalytic activity.

An efficient one-pot synthesis of N,N′-disubstituted phenylureas and N-aryl carbamates using hydroxylamine-O-sulfonic acid

We have developed an efficient one-pot method for the microwave-assisted synthesis of ureas and carbamates via a proposed Lossen rearrangement. Herein we report the first examples of the direct conversion of benzoyl chlorides into N,N′-disubstituted ureas and N-aryl carbamates using hydroxylamine-O-sulfonic acid as reagent. Using our general method, we have produced 11 examples of N,N′-disubstituted phenylureas in yields up to 95% using various substituted anilines, and primary and secondary amines. Additionally, we were able to generate a series of N-aryl carbamates in moderate yields using primary, secondary and tertiary alcohols.