3197-44-2

Basic information

• Product Name: (R)-Piperidin-2-ylMethanol
• Synonyms: (R)-Piperidin-2-ylMethanol;(R)-2-HYDROXYMETHYLPIPERIDINE;(R)-piperidin-2-ylmethanol hydrochloride;(2R)-2-Piperidinemethanol;(R)-Piperidine-2-ylmethanol
• CAS NO: 3197-44-2
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.17352
• EINECS: -0
• Mol File: 3197-44-2.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 221.2°C at 760 mmHg
• Flash Point: 90.9°C
• Appearance: /
• Density: 0.951g/cm³
• Vapor Pressure: 0.0225mmHg at 25°C
• Refractive Index: 1.451
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 15.08±0.10(Predicted)
• CAS DataBase Reference: (R)-Piperidin-2-ylMethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-Piperidin-2-ylMethanol(3197-44-2)
• EPA Substance Registry System: (R)-Piperidin-2-ylMethanol(3197-44-2)

Safety Data

• Hazardous Substances Data: 3197-44-2(Hazardous Substances Data)

Usage

General Description

(R)-Piperidin-2-ylMethanol, also known as 2-hydroxy-N-((2S)-2-piperidinylmethyl)piperidine, is a chemical compound with the molecular formula C10H21NO. It is a chiral compound with a piperidine ring and a hydroxymethyl group. It is commonly used as an intermediate in the synthesis of pharmaceutical compounds, such as antihistamines and antipsychotic drugs. (R)-Piperidin-2-ylMethanol has potential applications in medicinal chemistry and drug development due to its structural features and pharmacological properties. Additionally, it may serve as a building block for the preparation of various organic molecules and bioactive substances.

InChI:InChI=1/C6H13NO/c8-5-6-3-1-2-4-7-6/h6-8H,1-5H2/t6-/m0/s1

Upstream product

• 35677-83-9 (+)-2R-Piperidine-2-carboxylic acid methyl ester 
• 73229-30-8 hepta-5,6-diene-1-ol 
• 928-90-5 5-hexyl-1-ol 
• 107970-42-3 N-(hepta-5,6-dien-1-yl)-4-methylbenzenesulfonamide 
• 60343-64-8 (R)-(1-tosylpiperidin-2-yl)methanol 
• 182969-96-6 (Z)/(E)-ethyl 3-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-bromo-2-propenoate 
• 1353042-37-1 (R)-ethyl 6-oxopiperidine-2-carboxylate 
• 189188-59-8 (2R,3R)-ethyl 1-benzyl-3-((S)-1,2-dihydroxyethyl)aziridine-2-carboxylate 
• 160885-25-6 (2R,3R,4S)-1-benzyl-3-(2,2-dimethyl-1,3-dioxolan-4-yl)-aziridine-2-carboxylic acid ethyl ester 
• 4043-87-2 pipecolic Acid 
• 134441-61-5 tert-butyl (2R)-2-(hydroxymethyl)piperidine-1-carboxylate 
• 113965-39-2 2,2-Dimethyl-propionic acid cyclopent-1-enylmethyl ester 
• 6140-65-4 1-cyclopentene-1-carboxaldehyde 
• 1120-80-5 cyclopent-1-ene-1-methanol 

Downstream Products

• 134441-61-5 tert-butyl (2R)-2-(hydroxymethyl)piperidine-1-carboxylate 
• 539823-49-9 (R)-2-hydroxymethyl-1-(2-iodobenzoyl)piperidine 
• 856015-17-3 (R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-piperidine 
• 539823-50-2 (R,E)-methyl 3-[1-(2-iodobenzoyl)piperidin-2-yl]acrylate 
• 134526-69-5 tert-butoxycarbonyl-D-piperidine-2-carboxaldehyde 
• 6879-74-9 himbacine 
• 518-99-0 himbeline 
• 192133-54-3 (2R,6S)-2-Benzenesulfonylmethyl-6-methyl-piperidine 
• 168417-05-8 (2R,6S)-2-Benzenesulfonylmethyl-1,6-dimethyl-piperidine 
• 192133-21-4 (2S,6R)-2-Methyl-6-phenylsulfanylmethyl-piperidine-1-carboxylic acid tert-butyl ester 
• 192133-22-5 (2R,6S)-2-Benzenesulfonylmethyl-6-methyl-piperidine-1-carboxylic acid tert-butyl ester 
• 192133-57-6 (2R,6S)-2-[2-Benzenesulfonyl-1-hydroxy-2-((1S,3S,3aS,4R,4aS,8aR,9aS)-1-methoxy-3-methyl-dodecahydro-naphtho[2,3-c]furan-4-yl)-ethyl]-6-methyl-piperidine-1-carboxylic acid tert-butyl ester 
• 192133-20-3 (R)-2-Phenylsulfanylmethyl-piperidine-1-carboxylic acid tert-butyl ester 
• 85387-43-5 (R)-N-Benzylpiperidine-2-methanol 

Relevant articles and documents

Enantiodivergent synthesis of the quinolizidine poison frog alkaloid 195C

Herein, we describe the enantiodivergent synthesis of the 1,4-cis-disubstituted quinolizidine alkaloid 195C. Although the stereoselectivity of the final hydrogenation reaction was low, we have proposed the first chiral total synthesis of both (-)- and (+)-195C as an enantiodivergent process.

Enantioselective syntheses of (R)-pipecolic acid, (2R,3R)-3-hydroxypipecolic acid, β-(+)-conhydrine and (-)-swainsonine using an aziridine derived common chiral synthon

Concise total syntheses of (R)-pipecolic acid, (R)-ethyl-6-oxopipecolate, (2R,3R)-3-hydroxypipecolic acid and formal syntheses of β-(+)-conhydrine, (-)-lentiginosine, (-)-swainsonine and 1,2-di-epi-swainsonine have been accomplished starting from a common chiral synthon. The present strategy employs regioselective aziridine ring opening, Wittig olefination and RCM as the key chemical transformations.

QUINAZOLINE DERIVATIVES

The invention provided a compound of formula (I) for use in the treatment of disease, in particular proliferative diseases such as cancer and for use in the preparation of medicaments for use in the treatment of proliferative diseases; the invention also