327-52-6

Basic information

• Product Name: 1-Bromo-2,4,5-trifluorobenzene
• Synonyms: 1-BROMO-2,4,5-TRIFLUOROBENZENE;2,4,5-TRIFLUOROBROMOBENZENE;2-BROMO-1,4,5-TRIFLUOROBENZENE;2,4,5-TRIFLUOROBENZOBROMIDE;1-Bromo-2,4,5-trifluorobenzene 99%;1-Bromo-2,4,5-trifluorobenzene99%;1-BROMO-2,4,5-TRIFLUOROBENZENE 98+%;2,4,5-Trifluorophenyl bromide
• CAS NO: 327-52-6
• Molecular Formula: C₆H₂BrF₃
• Molecular Weight: 210.98
• EINECS: 206-318-8
• Product Categories: Aromatic Hydrocarbons (substituted) & Derivatives;Miscellaneous;Benzenes;Aryl;C6;Halogenated Hydrocarbons
• Mol File: 327-52-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: −19 °C(lit.)
• Boiling Point: 144 °C(lit.)
• Flash Point: 132 °F
• Appearance: clear slightly yellow liquid
• Density: 1.802 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00557mmHg at 25°C
• Refractive Index: n20/D 1.485(lit.)
• Storage Temp.: 2-8°C
• Solubility: water: insoluble
• Water Solubility: insoluble
• BRN: 1636588
• CAS DataBase Reference: 1-Bromo-2,4,5-trifluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Bromo-2,4,5-trifluorobenzene(327-52-6)
• EPA Substance Registry System: 1-Bromo-2,4,5-trifluorobenzene(327-52-6)

Safety Data

• Hazard Codes: Xi,F
• Statements: 36/37/38-10
• Safety Statements: 26-36/37/39-37/39-16
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 327-52-6(Hazardous Substances Data)

Usage

Description

1-Bromo-2,4,5-trifluorobenzene is an organic compound characterized by the presence of a bromine atom and three fluorine atoms attached to a benzene ring. It is a versatile intermediate in the synthesis of various chemical compounds and has applications in different industries.

Uses

Used in Pharmaceutical Industry:
1-Bromo-2,4,5-trifluorobenzene is used as an intermediate for the synthesis of quinolone antibacterial agents, which are important in the development of new drugs to combat bacterial infections.
Used in Liquid Crystal Industry:
1-Bromo-2,4,5-trifluorobenzene serves as an intermediate in the production of liquid crystals, which are widely used in display technologies such as televisions, computer monitors, and smartphones.
Used in Chemical Synthesis:
1-Bromo-2,4,5-trifluorobenzene is employed in the synthesis of various 3-substituted-2,4,5-trifluorobenzoic acids, including 3-ethenyl, 3-ethynyl, 3-aryl, and 3-cyclopropyl derivatives. These compounds have potential applications in various fields, such as pharmaceuticals, materials science, and agrochemicals.

InChI:InChI=1/C8H5F3N2/c9-8(10,11)6-3-5(4-12)1-2-7(6)13/h1-3H,13H2

Upstream product

• 367-23-7 1,2,4-trifluorobenzene 
• 7726-95-6 bromine 
• 367-34-0 2,4,5-trifluoroaniline 
• 446-35-5 2,4-Difluoronitrobenzene 
• 611-06-3 2,4-dichloronitrobenzene 
• 541-73-1 1,3-Dichlorobenzene 
• 367-25-9 2,4-difluorophenylamine 
• 62-53-3 aniline 
• 363-80-4 2,3,5-trifluoro aniline 

Downstream Products

• 2358-29-4 2,3,6-trifluorobenzoic acid 
• 446-17-3 2,4,5-trifluorobenzoic acid 
• 118829-12-2 3-bromo-2,5,6-trifluorobenzoic acid 
• 147425-25-0 1-Bromo-2,4,5-trifluoro-3-iodo-benzene 
• 147425-22-7 2-(3-Bromo-2,5,6-trifluoro-phenyl)-propan-2-ol 
• 98349-22-5 2,4,5-trifluorobenzonitrile 
• 306307-99-3 P,P'-(1,2-ethanediyl)bis[bis(2,4,5-trifluorophenyl)phosphane] 
• 1256470-41-3 ethyl 2-(2,4,5-trifluorophenyl)acetate 
• 1260029-44-4 (E)-4-(2,4,5-trifluoro-phenyl)-but-2-enoic acid methyl ester 
• 209995-38-0 (2,4,5-trifluorophenyl)acetic acid 
• 1048703-14-5 (R)-tert-butyl (4-hydroxy-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate 
• 1380243-33-3 C₁₇H₁₈F₃NO₂S₂ 
• 1380243-41-3 C₂₄H₂₄F₃NO 
• 1380243-39-9 C₂₂H₂₆F₃NO₃ 

Relevant articles and documents

Novel preparation method of 2, 4, 5-trifluorophenylacetic acid

The invention discloses a novel preparation method of 2, 4, 5-trifluorophenylacetic acid, which belongs to the technical field of preparation of medical intermediates, and comprises the following preparation steps: carrying out nitration reaction on sulfuric acid and m-dichlorobenzene to obtain an intermediate II; adding the intermediate II, a phase transfer catalyst and potassium fluoride into an aprotic solvent to obtain an intermediate III; performing hydrogenation reaction on the intermediate III to obtain an intermediate IV; carrying out diazotization reaction on the intermediate IV, nitrosyl sulfuric acid and sodium fluoborate to obtain an intermediate V; performing cracking reaction on the intermediate V to obtain an intermediate VI; carrying out reduction reaction on the intermediate VI, and then carrying out bromination reaction on the intermediate VI and liquid bromine to obtain an intermediate VII; subjecting the intermediate VII to a substitution reaction with diethyl malonate, and obtaining 2, 4, 5-trifluorophenylacetic acid after hydrolysis and purification. A novel synthesis route is provided, the problem that technological operation is tedious is solved, the requirements for reaction and operation conditions are low, anhydrous and oxygen-free reaction conditions are not needed, the method is suitable for industrial production, and the yield and purity are greatly improved.

Efficient preparation method of 2, 4, 5-trifluorophenylacetic acid

The invention discloses an efficient preparation method of 2, 4, 5-trifluorophenylacetic acid and belongs to the technical field of synthesis of a pharmaceutical intermediate. The preparation method comprises synthesis of 2, 3, 5-trifluoroaniline, synthesis of 1, 2, 4-trifluorobenzene, synthesis of trifluorobromobenzene and synthesis of a desired product 2, 4, 5-trifluorophenylacetic acid. The preparation method is simple and easy to operate, utilizes cheap and easily available raw materials and has high reaction efficiency and good repeatability.

PROCESS FOR THE PREPARATION OF ORGANIC BROMIDES

The present invention provides a process for the preparation of organic bromides, by a radical bromodecarboxylation of carboxylic acids with a bromoisocyanurate.