3296-05-7

Basic information

• Product Name: 1-Azido-4-chlorobenzene solution
• Synonyms: 1-Azido-4-chlorobenzene solution;Benzene, 1-azido-4-chloro-;1-Azido-4-chlorobenzene solution ~0.5 M in tert-butyl methyl ether, >=95.0% (HPLC)
• CAS NO: 3296-05-7
• Molecular Formula: C₆H₄ClN₃
• Molecular Weight: 153.56906
• Mol File: 3296-05-7.mol
• Article Data: 134

Chemical Properties

• Melting Point: 20°C
• Boiling Point: 252.42°C (rough estimate)
• Flash Point: -30℃
• Appearance: /
• Density: 1.2634
• Refractive Index: 1.6000 (estimate)
• Storage Temp.: ?20°C
• BRN: 1210408
• CAS DataBase Reference: 1-Azido-4-chlorobenzene solution(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Azido-4-chlorobenzene solution(3296-05-7)
• EPA Substance Registry System: 1-Azido-4-chlorobenzene solution(3296-05-7)

Safety Data

• Hazard Codes: F,Xn
• Statements: 11-22-38-43
• Safety Statements: 16-36/37
• RIDADR: UN 2398 3 / PGII
• WGK Germany: 3
• Hazardous Substances Data: 3296-05-7(Hazardous Substances Data)

Usage

Description

1-Azido-4-chlorobenzene solution is a chemical compound that consists of a benzene ring with an azido group and a chlorine substituent. It is commonly used as a reagent in organic synthesis and as a precursor for various pharmaceutical and agrochemical products. The azido group in the compound makes it highly reactive and capable of participating in a variety of chemical reactions, such as azide-alkyne cycloaddition and nucleophilic aromatic substitution. The solution is typically handled under strict safety precautions due to its explosive nature and potential toxicity. Overall, 1-Azido-4-chlorobenzene solution is an important and versatile chemical reagent with a wide range of applications in synthetic chemistry.

Uses

Used in Organic Synthesis:
1-Azido-4-chlorobenzene solution is used as a reagent for various organic synthesis processes due to its high reactivity and ability to participate in different chemical reactions.
Used in Pharmaceutical Industry:
1-Azido-4-chlorobenzene solution is used as a precursor for the development of pharmaceutical products, contributing to the synthesis of new drugs and therapeutic agents.
Used in Agrochemical Industry:
1-Azido-4-chlorobenzene solution is used as a precursor for the development of agrochemical products, such as pesticides and herbicides, to improve agricultural productivity and crop protection.
Used in Research and Development:
1-Azido-4-chlorobenzene solution is used in research and development settings to explore new chemical reactions and investigate its potential applications in various fields, including materials science and nanotechnology.

InChI:InChI=1/C6H4ClN3/c7-5-1-3-6(4-2-5)9-10-8/h1-4H

Upstream product

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• 28149-53-3 HBN₄(C₆H₄-4-Cl)2 
• 673-41-6 p-chlorobenzenediazonium tetrafluoroborate 
• 106-47-8 4-chloro-aniline 
• 7664-93-9 sulfuric acid 
• 134861-42-0 1-(4-chloro-phenylazo)-acetaldehyde-oxime 

Downstream Products

• 90861-96-4 4-chloro-2-(tetrahydrothiophen-2-yl)aniline 
• 106-47-8 4-chloro-aniline 
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• 20320-16-5 1-(4-chlorophenyl)-1H-1,2,3-triazole 
• 128654-42-2 9-(4-chlorophenyl)-9-azabicyclo<6.1.0>nonane 
• 114462-77-0 1-(4-Chloro-phenyl)-5-methoxycarbonylmethyl-1H-[1,2,3]triazole-4-carboxylic acid methyl ester 
• 109481-01-8 4-[3-(4-Chloro-phenyl)-5-nitro-3H-[1,2,3]triazol-4-yl]-morpholine 
• 624-92-0 Dimethyldisulphide 
• 21502-31-8 4-chloro-2-[(methylthio)methyl]aniline 
• 139871-56-0 1-(4-Chlorophenyl)-5-(N-methyl-N-acetamido)-1,2,3-triazoline 
• 128654-41-1 8-(4-chlorophenyl)-8-azabicyclo<5.1.0>octane 
• 53165-13-2 4-Chlor-2-(thiophenoxymethyl)anilin 
• 882-33-7 diphenyldisulfane 
• 73079-07-9 10-(4-chlorophenylimino)anthrone 

Relevant articles and documents

Design and synthesis of 1,4-disubstituted 1,2,3-triazoles: Biological evaluation, in silico molecular docking and ADME screening

In this study, propargyl compounds were synthesized from 4-hydroxybenzaldehyde and 3?methoxy-4-hydroxybenzaldehyde (2a-2b). As a result of click reactions of synthesized propargyl compounds (2a-b) with organic azides (4a-4e), carbonyl compounds (5a-5 h) h

Triazole [5, 4-d] pyrimidone tricyclic compounds as well as preparation method and application thereof

The invention relates to triazole [5, 4-d] pyrimidone tricyclic compounds as well as a preparation method and application thereof.The triazole [5, 4-d] pyrimidone tricyclic compounds are prepared by following steps: taking different substituted anilines a

Synthesis and rational design of new appended 1,2,3-triazole-uracil ensembles as promising anti-tumor agents via in silico vegfr-2 transferase inhibition

Angiogenesis inhibition is a key step towards the designing of new chemotherapeutic agents. In a view to preparing new molecular entities for cancer treatment, eighteen 1,2,3-triazole-uracil ensembles 5a–r were designed and synthesized via the click reaction. The ligands were well characterized using1 H-,13 C-NMR, elemental analysis and ESI-mass spectrometry. The in silico binding propinquities of the ligands were studied sequentially in the active region of VEGFR-2 using the Molegro virtual docker. All the compounds produced remarkable interactions and potentially inhibitory ligands against VEGFR-2 were obtained with high negative binding energies. Drug-likeness was assessed from the ADME properties. Cytotoxicity of the test compounds was measured against HeLa and HUH-7 tumor cells and NIH/3T3 normal cells by MTT assay. Compound 5h showed higher growth inhibition activity than the positive control, 5-fluorouracil (5-FU), against both HeLa and HUH-7 cells with IC50 values of 4.5 and 7.7 μM respectively. Interestingly, the compounds 5a–r did not show any cytotoxicity towards the normal cell lines. The results advance the position of substituted triazoles in the area of drug design with no ambiguity.