33496-83-2

Basic information

• Product Name: Cyclohexanone, 3,3,5-trimethyl-, (5S)-
• CAS NO: 33496-83-2
• Molecular Formula: C9H16O
• Molecular Weight: 140.225
• Mol File: 33496-83-2.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: Cyclohexanone, 3,3,5-trimethyl-, (5S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanone, 3,3,5-trimethyl-, (5S)-(33496-83-2)
• EPA Substance Registry System: Cyclohexanone, 3,3,5-trimethyl-, (5S)-(33496-83-2)

Safety Data

• Hazardous Substances Data: 33496-83-2(Hazardous Substances Data)

Upstream product

• 78-59-1 3,5,5-Trimethylcyclohex-2-en-1-one 
• 873-94-9 dihydroisophorone 
• 147-85-3 L-proline 
• 67217-68-9 1,1-dimethoxy-3,3,5-trimethyl-cyclohexane 

Relevant articles and documents

Heterogeneously catalyzed asymmetric C=C hydrogenation: Origin of enantioselectivity in the proline-directed Pd/isophorone system

We have studied the proline-directed, Pd-catalyzed enantioselective hydrogenation of isophorone in the liquid state using a variety of methods. Our results unambiguously reveal the true reaction pathway and demonstrate that all earlier mechanistic hypothe

P-CHIRAL PHOSPHINE LIGANDS AND USE THEREOF FOR ASYMMETRIC SYNTHESIS

The present invention relates to chiral compounds with two optically active phosphorus atoms, chiral transition metal catalysts which comprise these compounds as ligands, a process for preparing the P-chiral compounds and processes for asymmetric synthesis using the chiral transition metal catalysts. The present invention specifically relates to a process for preparing an optically active carbonyl compound by asymmetric hydrogenation of a prochiral α,β-unsaturated carbonyl compound with hydrogen in the presence of an optically active transition metal catalyst according to the invention. Yet more specifically, the present invention relates to a process for the asymmetric hydrogenation of citral, and also a process for preparing optically active menthol.

P-Chirogenic Xantphos Ligands and Related Ether Diphosphines: Synthesis and Application in Rhodium-Catalyzed Asymmetric Hydrogenation

A series of P-chirogenic Xantphos ligands and related diaryl ether diphosphines have been synthesized by a modification of the well-established Jugé method. The approach consists of the in situ deboranation of the chiral ephedrine-based phosphinite before the P-C coupling takes place. The stereochemical integrity of the stereocenters of the diphosphines during synthesis, long-time storage, and catalytic application was evaluated. In the rhodium-catalyzed asymmetric hydrogenation of isophorone as a model substrate for industrially relevant prostereogenic enones with some of the diphosphines, almost complete conversion, high chemoselectivity, and 96% ee were achieved.