336182-29-7

Basic information

• Product Name: 4-Bromo-N-isopropylbenzamide
• Synonyms: 4-Bromo-N-isopropylbenzamide;N-Isopropyl 4-bromobenzamide
• CAS NO: 336182-29-7
• Molecular Formula: C₁₀H₁₂BrNO
• Molecular Weight: 242.11
• Product Categories: blocks;Bromides;Carboxes
• Mol File: 336182-29-7.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 344.6°Cat760mmHg
• Flash Point: 162.2°C
• Appearance: /
• Density: 1.349g/cm³
• Vapor Pressure: 6.52E-05mmHg at 25°C
• Refractive Index: 1.545
• PKA: 14.33±0.46(Predicted)
• CAS DataBase Reference: 4-Bromo-N-isopropylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-N-isopropylbenzamide(336182-29-7)
• EPA Substance Registry System: 4-Bromo-N-isopropylbenzamide(336182-29-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-52
• Hazardous Substances Data: 336182-29-7(Hazardous Substances Data)

Usage

General Description

4-Bromo-N-isopropylbenzamide is a chemical compound with the molecular formula C10H12BrNO. It is also known by the chemical name N-(4-bromophenyl)-propan-2-yl benzamide. 4-Bromo-N-isopropylbenzamide is an aromatic amide that contains a benzene ring with a bromine substitution and a N-isopropyl group attached to the amide nitrogen. It is commonly used as a building block in organic synthesis and pharmaceutical research. It may also have potential applications in medicinal chemistry for the development of new drugs. The compound's properties and uses make it a valuable and versatile chemical in various industries.

InChI:InChI=1/C10H12BrNO/c1-7(2)12-10(13)8-3-5-9(11)6-4-8/h3-7H,1-2H3,(H,12,13)

Upstream product

• 79606-46-5 4-bromo-N,N-diisopropylbenzamide 
• 623-00-7 4-bromobenzenecarbonitrile 
• 67-63-0 isopropyl alcohol 
• 75-31-0 isopropylamine 
• 586-75-4 4-chlorobenzoyl chloride 
• 1122-91-4 4-bromo-benzaldehyde 
• 586-76-5 4-Bromobenzoic acid 
• 2700-30-3 N,N-diisorpopylformamide 
• 106-38-7 para-bromotoluene 
• 99-73-0 para-bromophenacyl bromide 
• 693-13-0 diisopropyl-carbodiimide 

Downstream Products

• 1416784-40-1 4-{3-(cyanomethyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-1-yl}-N-isopropylbenzamide 
• 1416784-90-1 4-{3-(cyanomethyl)-3-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-1-yl}-N-isopropylbenzamide 
• 60376-97-8 N-(4-bromobenzyl)isopropylamine 
• 99177-33-0 (4-bromo-benzyl)-isopropyl-amine; hydrochloride 
• 1122-91-4 4-bromo-benzaldehyde 
• 27895-62-1 N-4-bromobenzylideneisopropylamine 
• 623-00-7 4-bromobenzenecarbonitrile 
• 1138239-38-9 4-(4-isopropylcarbamoyl-phenyl)-butyric acid ethyl ester 

Relevant articles and documents

Hydrogenation of Secondary Amides using Phosphane Oxide and Frustrated Lewis Pair Catalysis

The metal-free catalytic hydrogenation of secondary carboxylic acid amides is developed. The reduction is realized by two new catalytic reactions. First, the amide is converted into the imidoyl chloride by triphosgene (CO(OCCl3)2) using novel phosphorus(V) catalysts. Second, the in situ generated imidoyl chlorides are hydrogenated in high yields by an FLP-catalyst. Mechanistic and quantum mechanical calculations support an autoinduced catalytic cycle for the hydrogenation with chloride acting as unusual Lewis base for FLP-mediated H2-activation.

N-Heterocyclic Carbene-Mediated Microfluidic Oxidative Electrosynthesis of Amides from Aldehydes

A flow process for N-Heterocyclic Carbene (NHC)-mediated anodic oxidative amidation of aldehydes is described, employing an undivided microfluidic electrolysis cell to oxidize Breslow intermediates. After electrochemical oxidation, the reaction of the intermediate N-acylated thiazolium cation with primary amines is completed by passage through a heating cell to achieve high conversion in a single pass. The flow mixing regimen circumvented the issue of competing imine formation between the aldehyde and amine substrates, which otherwise prevented formation of the desired product. High yields (71-99%), productivities (up to 2.6 g h-1), and current efficiencies (65-91%) were realized for 19 amides.

Syntheses of amides via iodine-catalyzed multiple sp3 C-H bonds oxidation of methylarenes and sequential coupling with N,N-dialkylformamides

The oxidative coupling of methylarenes and N,N-dialkylformamides was developed, and the appropriate reaction conditions were established. By using I2 as the catalyst, and tert-butyl hydroperoxide (TBHP) as the oxidant, the reaction provided N,N