3389-54-6

Basic information

• Product Name: 1-BENZOYLPYRROLIDINE
• Synonyms: 1-BENZOYLPYRROLIDINE;(Pyrrolizino)(phenyl)methanone;Pyrrolizinophenyl ketone
• CAS NO: 3389-54-6
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.23
• Mol File: 3389-54-6.mol
• Article Data: 229

Chemical Properties

• Melting Point: 102 °C
• Boiling Point: 191-193 °C(Press: 12 Torr)
• Appearance: /
• Density: 1.117±0.06 g/cm3(Predicted)
• PKA: -1.14±0.20(Predicted)
• CAS DataBase Reference: 1-BENZOYLPYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZOYLPYRROLIDINE(3389-54-6)
• EPA Substance Registry System: 1-BENZOYLPYRROLIDINE(3389-54-6)

Safety Data

• Hazardous Substances Data: 3389-54-6(Hazardous Substances Data)

Usage

Description

1-Benzoylpyrrolidine, also known as N-benzoylpyrrolidine or N-phenylpyrrolidin-2-one, is a chemical compound with the molecular formula C12H11NO. It is a white to off-white solid that is primarily used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. Additionally, it is recognized for its psychoactive effects and is classified as a designer drug, which has led to its regulation in various jurisdictions due to its potential for abuse and addiction. Careful handling and adherence to safety guidelines are essential to minimize potential hazards associated with 1-benzoylpyrrolidine.

Uses

Used in Pharmaceutical Industry:
1-Benzoylpyrrolidine is used as a chemical intermediate for the synthesis of various pharmaceuticals and organic compounds. Its unique structure and properties make it a valuable component in the development of new drugs and medications.
Used in Research and Development:
In the field of research and development, 1-benzoylpyrrolidine is utilized for studying its psychoactive effects and potential applications in the treatment of certain conditions. Its psychoactive properties provide insights into the mechanisms of action and potential therapeutic uses.

Upstream product

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Downstream Products

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Relevant articles and documents

Direct synthesis of N-acylpyrrolidines from tetrahydrofuran and nitriles of aliphatic and aromatic acids on zeolite catalysts under supercritical conditions

The tetrahydrofuran-nitrile (CH3CN, n-C4H 9CN, C6H5CN)-zeolite (faujasites, mordenite, beta, pentasils) system and its transformations under supercritical conditions were studied. The feasibility of d

Photocatalytic aldehydes/alcohols/toluenes oxidative amidation over bifunctional Pd/MOFs: Effect of Fe-O clusters and Lewis acid sites

Heterogeneous photocatalytic organic synthesis is fascinating because of the utilization of ubiquitous solar light for chemical transformations. Here, three Fe-MOFs with different Fe-O clusters, Lewis acid sites and morphologies were synthesized through coordination structure engineering. Pd/Fe-MOFs nanocomposites were used to challenge the amide bond green synthesis with visible light. Pd/MIL-101(Fe) exhibited the best photocatalytic performance due to the easily excited Fe3-μ3-oxo clusters for light absorption, the efficient photogenerated carriers separation and migration, the large amount of Lewis acid sites based aldehydes and amines condensation promotion and the efficient O2 reduction to superoxide radicals over photogenerated electron-rich Pd NPs. Various aldehydes, alcohols and toluenes could be transformed to amide compounds with amines over Pd/MIL-101(Fe) with just oxygen or air as the green oxidant and water as the by-product. One-pot C–C cross-coupling and photo-redox C–N coupling cascade reactions could also be achieved over Pd/MIL-101(Fe). This work shed light on the efficient and sustainable amide bonds synthesis.

Amide Bond Formation via Aerobic Photooxidative Coupling of Aldehydes with Amines Catalyzed by a Riboflavin Derivative

We report an effective, operationally simple, and environmentally friendly system for the synthesis of tertiary amides by the oxidative coupling of aromatic or aliphatic aldehydes with amines mediated by riboflavin tetraacetate (RFTA), an inexpensive organic photocatalyst, and visible light using oxygen as the sole oxidant. The method is based on the oxidative power of an excited flavin catalyst and the relatively low oxidation potential of the hemiaminal formed by amine to aldehyde addition.