3402-74-2

Basic information

• Product Name: p-(p-nitrophenoxy)toluene
• Synonyms: p-(p-nitrophenoxy)toluene;1-Methyl-4-(4-nitrophenoxy)benzene
• CAS NO: 3402-74-2
• Molecular Formula: C₁₃H₁₁NO₃
• Molecular Weight: 229.23134
• EINECS: 222-276-3
• Mol File: 3402-74-2.mol
• Article Data: 54

Chemical Properties

• Melting Point: 69°C
• Boiling Point: 371.13°C (rough estimate)
• Flash Point: 142°C
• Appearance: /
• Density: 1.2084 (rough estimate)
• Vapor Pressure: 0.00025mmHg at 25°C
• Refractive Index: 1.5500 (estimate)
• CAS DataBase Reference: p-(p-nitrophenoxy)toluene(CAS DataBase Reference)
• NIST Chemistry Reference: p-(p-nitrophenoxy)toluene(3402-74-2)
• EPA Substance Registry System: p-(p-nitrophenoxy)toluene(3402-74-2)

Safety Data

• Hazardous Substances Data: 3402-74-2(Hazardous Substances Data)

Usage

General Description

P-(p-nitrophenoxy)toluene, also known as nitrophenoxytoluene, is a chemical compound with the molecular formula C14H11NO3. It is a toluene derivative that contains a nitrophenyl ether functional group, which gives it a yellow color. p-(p-nitrophenoxy)toluene is mainly used as an intermediate in organic synthesis and in the manufacturing of dyes, pharmaceuticals, and agrochemicals. It is also used as a reagent in research laboratories for various organic transformations. Nitrophenoxytoluene is a potentially hazardous chemical and should be handled with care due to its toxic and flammable properties.

InChI:InChI=1/C13H11NO3/c1-10-2-6-12(7-3-10)17-13-8-4-11(5-9-13)14(15)16/h2-9H,1H3

Upstream product

• 106-44-5 p-cresol 
• 100-00-5 4-chlorobenzonitrile 
• 78-32-0 tri-p-cresyl phosphate 
• 1121-70-6 sodium 4-methylphenoxide 
• 586-78-7 para-nitrophenyl bromide 
• 62790-85-6 tert-Butyl(dimethyl)-(4-methylphenoxy)silane 
• 350-46-9 4-Fluoronitrobenzene 
• 100-02-7 4-nitro-phenol 
• 352-32-9 p-fluorotoluene 
• 865-47-4 potassium tert-butylate 
• 106-43-4 para-chlorotoluene 
• 100-25-4 para-dinitrobenzene 
• 73177-96-5 <(hydroxy)(tosyloxy)iodo>-p-toluene 
• 1428064-59-8 2,4-dimethoxyphenyl(4-methylphenyl)iodonium tosylate 

Downstream Products

• 70718-57-9 4-bromomethyl-4'-nitrodiphenyl ether 
• 38100-81-1 (2-bromo-4-methyl-phenyl)-(4-nitro-phenyl)-ether 
• 2914-76-3 (4-methyl-2-nitro-phenyl)-(4-nitro-phenyl)-ether 
• 331974-00-6 N-(4-(p-tolyloxy)phenyl)acetamide 
• 1179802-07-3 1-chlorosulfonyl-2-(4'-nitrophenoxy)-5-methylbenzene 

Relevant articles and documents

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Hydrothermal treatment of gadolinium nitrate and 2,6-naphthalenedicarboxylic acid (H2NDC) afforded a new metal-organic framework compound, {[Gd4(NDC)6(H2O)6]·2H2O}n(1). Compound 1 has been characterized by single-crystal X-ray crystallography, elemental analysis, FT-IR spectroscopy, therrmogravimetric analysis (TGA) and powder X-ray diffraction analysis. It is crystallized in the monoclinic system with the P21/n space group. Four crystallographically distinct Gd (III) centres are interconnected with each other through bridged carboxylato oxygen atoms and water molecules to form tetranuclear secondary building units, which are further connected through the carboxylato ligand and the network propagates along the crystallographic ac plane to form a 2D structure. Subsequent reinforcement from the remaining carboxylato oxygen atoms gives rise to a robust 3D framework structure. Thermogravimetric analysis demonstrates that compound 1 is fairly stable after dehydration under a nitrogen atmosphere. Notably, compound 1 is capable of catalyzing the O-arylation reaction efficiently between substituted phenols and bromoarene under heterogeneous conditions at 80 °C to afford unsymmetrical diarylethers.

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The structure is shown in the formula I, and the definition of each substituent is as described in the specification and the claims. The compounds of the invention are useful in the preparation of medicaments for the treatment of diseases or disorders mediated by TEAADs. (by machine translation)

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Interaction of chitosan (CS) with Fe3O4, followed by embedding Cu nanoparticles (NPs) on the magnetic surface through adsorption of Cu2+, and its reduction to Cuo via NaBH4, offers a reusable efficient catalyst (Fe3O4/CS-Cu NPs) that is employed in cross-coupling reactions of aryl halides with phenols, which affords the corresponding diaryl ethers, with good to excellent yields. The catalyst is completely recoverable from the reaction mixture by using an external magnet. It can be reused four times, without significant loss in its catalytic activity.