343781-53-3

Basic information

• Product Name: 2-Pyridinecarboxaldehyde, 3,6-dichloro-
• Synonyms: 2-Pyridinecarboxaldehyde, 3,6-dichloro-;3,6-Dichloro-2-pyridinecarboxaldehyde;2,5-Dichloropyridine-6-carboxaldehyde;3,6-Dichloropyridine-2-carboxaldehyde;3,6-Dichloro-2-formylpyridine, 3,6-Dichloropicolinaldehyde;3,6-dichloropyridine-2-carbaldehyde;3,6-Dichloropicolinaldehyde;2,5-dichloro-6-Pyridinecarboxaldehyde
• CAS NO: 343781-53-3
• Molecular Formula: C6H3Cl2NO
• Molecular Weight: 176.0
• Product Categories: Chlorinated heterocyclic series
• Mol File: 343781-53-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 234℃
• Flash Point: 95℃
• Appearance: /
• Density: 1.488
• Vapor Pressure: 0.054mmHg at 25°C
• Refractive Index: 1.608
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.60±0.10(Predicted)
• CAS DataBase Reference: 2-Pyridinecarboxaldehyde, 3,6-dichloro-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinecarboxaldehyde, 3,6-dichloro-(343781-53-3)
• EPA Substance Registry System: 2-Pyridinecarboxaldehyde, 3,6-dichloro-(343781-53-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 343781-53-3(Hazardous Substances Data)

Usage

General Description

2-Pyridinecarboxaldehyde, 3,6-dichloro- is a chemical compound with the molecular formula C7H5Cl2NO. It is a derivative of pyridinecarboxaldehyde, with chlorine atoms attached to the 3 and 6 positions of the pyridine ring. 2-Pyridinecarboxaldehyde, 3,6-dichloro- is used in chemical synthesis as a building block for the production of various organic compounds. It is also used in the pharmaceutical industry for the synthesis of different drugs and their intermediates. Additionally, it has been studied for its potential biological and pharmacological properties, including its antimicrobial and antifungal activities. However, it is important to handle this compound with care, as it is toxic and may cause skin and eye irritation upon contact.

InChI:InChI=1/C6H3Cl2NO/c7-4-1-2-6(8)9-5(4)3-10/h1-3H

Upstream product

• 16110-09-1 2,5 dichloropyridine 
• 68-12-2 N,N-dimethyl-formamide 
• 1702-17-6 Clopyralid 

Downstream Products

• 1699750-95-2 (E)-2-cyano-3-(3,6-dichloropyridin-2-yl)-N-(1-(4-(2-morpholinoethoxy)phenyl)butyl)acrylamide 

Relevant articles and documents

BENZOTHIOPHENE SULFONAMIDES AND OTHER COMPOUNDS THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN

The present invention relates to benzothiophene sulfonamides and other compounds that interact with glucokinase regulatory protein. In addition, the present invention relates to methods of treating type 2 diabetes, and other diseases and/or conditions where glucokinase regulatory protein is involved using the compounds, or pharmaceutically acceptable salts thereof, and pharmaceutical compositions that contain the compounds, or pharmaceutically acceptable salts thereof.

Strategies for the selective functionalization of dichloropyridines at various sites

Whereas 2,3-dichloropyridine and 2,5-dichloro-4-(lithiooxy)-pyridine undergo deprotonation exclusively at the 4- and 2-positions, respectively, optional site selectivity can be implemented with 2,5- and 3,4-dichloropyridine (which are attacked, depending on the choice of the reagents, at either the 4- or 6- and either the 2- and 5-positions, respectively). Upon treatment with lithium diisopropylamide, 2,4-dichloro-3-iodopyridine, 3,5-dichloro-4-bromopyridine and 2,6-dichloro-3-iodopyridine afford 5-, 2- and 4-lithiated intermediates, but the latter isomerize instantaneously to species in which lithium and iodine have swapped places, the driving force being the low basicity of C-Li bonds when flanked by two neighboring halogens.