34523-95-0Relevant articles and documents
Pharmaceutical composition containing novel quaternary ammonium compounds
-
, (2008/06/13)
Quaternary ammonium carbamate, thiocarbamate, dithiocarbamate and carbamide compounds. Typical examples are [C4 H9 NHCOO(CH2)2 N+(CH3)2 C12 H25 ]Br- [C4 H9 NHCSO(CH2)2 N+(CH3)2 C12 H25 ]Br- [CH3 NHCSS(CH2)2 N+(CH3)2 C12 H25 ]Br- [C2 H5 NHCONH(CH2)2 N+(CH3)2 C12 H25 ]Br- These compounds are effective against gram positive bacteria and fungi and reduce caries and inhibit formation of oral calculus. The thiocarbamates can be prepared by converting amino alcohols to sodium salts thereof with metallic sodium and reacting isothiocyanates with the sodium salts followed by quaternization. The carbamates can be prepared by reacting isocyanates with amino alcohols followed by quaternization. The dithiocarbamates can be prepared by reacting isothiocyanates with sodium salts of aminoalkanethiols followed by quaternization. The carbimides can be prepared by reacting isocyanates with alkanediamines followed by quaternization.
