347851-53-0

Basic information

• Product Name: dimethyl [(3S)-4-phenyl-3-[(benzyloxycarbonyl)amino]-2-oxobutyl]phosphonate
• Synonyms: dimethyl [(3S)-4-phenyl-3-[(benzyloxycarbonyl)amino]-2-oxobutyl]phosphonate
• CAS NO: 347851-53-0
• Molecular Weight: 405.387
• Mol File: 347851-53-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: dimethyl [(3S)-4-phenyl-3-[(benzyloxycarbonyl)amino]-2-oxobutyl]phosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl [(3S)-4-phenyl-3-[(benzyloxycarbonyl)amino]-2-oxobutyl]phosphonate(347851-53-0)
• EPA Substance Registry System: dimethyl [(3S)-4-phenyl-3-[(benzyloxycarbonyl)amino]-2-oxobutyl]phosphonate(347851-53-0)

Safety Data

• Hazardous Substances Data: 347851-53-0(Hazardous Substances Data)

Upstream product

• 35909-92-3 N-carbobenzoxy-L-phenylalanine methyl ester 
• 756-79-6 dimethyl methane phosphonate 

Downstream Products

• 1127928-28-2 (Z)-5-O-benzoyl-3-[1-(3-benzyloxycarbonylamino-2-oxo-4-phenyl)butylidene]-1,2-O-isopropylidene-α-D-erythro-pentofuranos-3-ulose 
• 1127928-42-0 (E)-5-O-benzoyl-3-[1-(3-benzyloxycarbonylamino-2-oxo-4-phenyl)butylidene]-1,2-O-isopropylidene-α-D-erythro-pentofuranos-3-ulose 
• 347851-58-5 tert-butyl (2RS,6S)-6-[N-(benzyloxycarbonyl)amino]-2-benzyl-5-oxo-7-phenyl-3-heptenyl ether 
• 347851-57-4 (2RS,6S)-6-[N-(benzyloxycarbonyl)amino]-2-benzyl-5-oxo-7-phenyl-3-hepten-1-ol 
• 347851-60-9 tert-butyl (2R,6S)-6-[N-(benzyloxycarbonyl)amino]-2-benzyl-5-oxo-7-phenyl-3-heptenyl ether 
• 347851-56-3 tert-butyldimethylsilyl-(2RS,6S)-6-[N-(benzyloxycarbonyl)amino]-2-benzyl-5-oxo-7-phenyl-3-heptenyl ether 

Relevant articles and documents

Design and synthesis of a conformationally restricted trans peptide isostere based on the bioactive conformations of saquinavir and nelfinavir

The design and synthesis of a new peptide isostere which contains a trans alkene core is described. The key step involves a Wadsworth-Emmons reaction between chiral aldehyde (2S)-9a and chiral phosphonate 7 under base-sensitive conditions to give a chiral enone (2R)-24a which was reduced to afford the desired trans alkene isosteres (2R,5R)-6a and (2R,5S)-6b (Scheme 6). A potential application of this isostere in the synthesis of HIV protease inhibitors is also discussed.