347860-45-1

Basic information

• Product Name: [1-(diphenoxyphosphonyl)-1-hydroxyethyl]-1-phosphonic acid methyl phenyl ester
• Synonyms: [1-(diphenoxyphosphonyl)-1-hydroxyethyl]-1-phosphonic acid methyl phenyl ester
• CAS NO: 347860-45-1
• Molecular Weight: 448.349
• Mol File: 347860-45-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [1-(diphenoxyphosphonyl)-1-hydroxyethyl]-1-phosphonic acid methyl phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [1-(diphenoxyphosphonyl)-1-hydroxyethyl]-1-phosphonic acid methyl phenyl ester(347860-45-1)
• EPA Substance Registry System: [1-(diphenoxyphosphonyl)-1-hydroxyethyl]-1-phosphonic acid methyl phenyl ester(347860-45-1)

Safety Data

• Hazardous Substances Data: 347860-45-1(Hazardous Substances Data)

Upstream product

• 108-95-2 phenol 
• 18351-42-3 dimethyl phenylphosphonite 
• 3426-89-9 phenyl phosphorodichloridite 

Relevant articles and documents

Bisphosphonate prodrugs. Synthesis and identification of (1-hydroxyethylidene)-1,1-bisphosphonic acid tetraesters by mass spectrometry, NMR spectroscopy and x-ray crystallography

The preparation and identification of symmetric, H3CC(OH)[P(O)(OR)2]2, where R=Me, Et, Pr1, Ph, and non-symmetric, H3CC(OH)[P(O)(OR1)(OR2)][P(O)(OR3)(O R4)], where R1=Me, R2=R3=R4=Ph; R1=R2=R3=Ph, R4=Me; R1=R3=Me, R2=R4=Ph; R1=R2=Et, Pr1, Ph and R3=R4=Me: tetraester derivatives of etidronate have been studied. Compounds were prepared from HP(O)(OR1)(OR2) and AcP(O)(OR3)(OR4) species under reflux. Mechanism studies have been made using HP(O)(OCD3)(OPh) and AcP(O)(OMe)(OPh) as starting materials. 1H, 13C, 31P NMR data and the MS fragmentation data in the gas phase are reported. The solid-state structures are given for three of the compounds, where R=Et, Ph and R1=R2=Ph, R3=R4=Me.