350986-48-0

Basic information

• Product Name: (Z)-β-(3,4,5-trimethoxyphenyl) α-cyano propenoic acid
• Synonyms: (Z)-β-(3,4,5-trimethoxyphenyl) α-cyano propenoic acid
• CAS NO: 350986-48-0
• Molecular Weight: 291.304
• Mol File: 350986-48-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (Z)-β-(3,4,5-trimethoxyphenyl) α-cyano propenoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-β-(3,4,5-trimethoxyphenyl) α-cyano propenoic acid(350986-48-0)
• EPA Substance Registry System: (Z)-β-(3,4,5-trimethoxyphenyl) α-cyano propenoic acid(350986-48-0)

Safety Data

• Hazardous Substances Data: 350986-48-0(Hazardous Substances Data)

Upstream product

• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 1537868-52-2 (5Z)-5-(3,4,5-trimethoxybenzylidene)-3-(4-nitrobenzyl)thiazolidine-2,4-dione 
• 175714-45-1 2-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazole 
• 29958-02-9 2-cyano-3-(3,4,5-trimethoxy-phenyl)propionic acid ethyl ester 
• 105-56-6 ethyl 2-cyanoacetate 
• 30563-87-2 2,4-diamino-5-(3,4,5-trimethoxybenzyl)-6-chloropyrimidine 
• 37389-83-6 2,4-diamino-5-(3',4',5'-trimethoxy-benzyl)-6-hydroxy-pyrimidine 
• 738-70-5 5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine 

Relevant articles and documents

An Efficient Knoevenagel Condensation Catalyzed by LaCl3.7H 2O in Heterogeneous Medium

Knoevenagel condensation was carried out in absence of solvent with a mild Lewis acid Lanthanum(III) chloride, to prepare substituted alkenes. A systematic study of the reaction to establish the generality of the method has been undertaken with various aldehydes and active methylene compounds.

Unprecedented reaction between ethyl α-cyanocinnamate and o-phenylenediamine: Development of an efficient method for the transfer hydrogenation of electronically depleted olefins

A reaction between ethyl α-cyanocinnamate and o-phenylenediamine under thermal conditions yielded 2-cyano-3-phenyl-propionic acid ethyl ester, 2-phenyl benzimidazole, and ethyl cyanoacetate. The mechanistic revelations led to the development of a simple and efficient transfer-hydrogenation process from the in situ generated benzimidazolines to activated olefins under solventless and catalyst-free conditions. Georg Thieme Verlag Stuttgart.

Synthesis and antileishmanial activity of α-cyano ethyl propenoates - A new class of antileishmanials

A number of α-cyano-β-substituted ethyl propenoates were synthesised by condensation of appropriate aldehydes with ethyl cyanoacetate in basic medium. These compounds have been studied for their antileishmanial activities in vivo in hamsters. Two compound