35120-33-3

Basic information

• Product Name: (S)-2-(CHLOROMETHYL)PYRROLIDINE HYDROCHLORIDE
• Synonyms: (S)-2-(CHLOROMETHYL)PYRROLIDINE HYDROCHLORIDE;Pyrrolidine, 2-(chloroMethyl)-, hydrochloride, (2S)-
• CAS NO: 35120-33-3
• Molecular Formula: C₅H₁₀ClN*ClH
• Molecular Weight: 0
• Mol File: 35120-33-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 137-138℃
• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (S)-2-(CHLOROMETHYL)PYRROLIDINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(CHLOROMETHYL)PYRROLIDINE HYDROCHLORIDE(35120-33-3)
• EPA Substance Registry System: (S)-2-(CHLOROMETHYL)PYRROLIDINE HYDROCHLORIDE(35120-33-3)

Safety Data

• Hazardous Substances Data: 35120-33-3(Hazardous Substances Data)

Usage

General Description

(S)-2-(Chloromethyl)pyrrolidine hydrochloride is a chemical compound with the formula C6H12ClN. It is a white to off-white crystalline powder that is soluble in water and ethanol. (S)-2-(CHLOROMETHYL)PYRROLIDINE HYDROCHLORIDE is used as a building block in the synthesis of pharmaceuticals, particularly in the production of drugs targeting central nervous system disorders. It is also used in the synthesis of various organic compounds and as a reagent in chemical reactions. Additionally, (S)-2-(Chloromethyl)pyrrolidine hydrochloride is used as a chiral auxiliary in asymmetric synthesis. Overall, this compound has applications in both the pharmaceutical and chemical industries.

Upstream product

• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 

Downstream Products

• 121451-45-4 (S)-bis<2-<<2-(chloromethyl)-1-pyrrolidinyl>carbonyl>phenyl> disulphide 
• 61350-66-1 (S)-2-(chloromethyl)-1-pyrrolidinecarboxylic acid phenylmethyl ester 

Relevant articles and documents

Pd(II) Complexes with Chelating Phosphinoferrocene Diaminocarbene Ligands: Synthesis, Characterization, and Catalytic Use in Pd-Catalyzed Borylation of Aryl Bromides

We developed a novel, straightforward route toward Pd(II)-aminocarbene complexes bearing a P-chelating phosphinoferrocenyl substituent based on a three-component reaction of 1′-(diphenylphosphino)-1-isocyanoferrocene (1) with [PdCl2(cod)] (cod = cycloocta-1,5-diene) and nucleophilic amines. Depending on the type of the amine, the reaction produced acyclic diaminocarbenes and their saturated (imidazolin-2-ylidene) and unsaturated (imidazol-2-ylidene) cyclic counterparts (NHCs). Using (S)-2-(chloromethyl)pyrrolidine as the nucleophile, this method afforded a separable pair of stable diastereomeric bicyclic imidazolin-2-ylidene carbenes with different configurations of the planar-chiral ferrocene unit. The prepared P-chelating carbenes were characterized using spectroscopic methods, X-ray crystallography, and DFT methods. The last were used to explain the formation of isomeric open diaminocarbenes featuring NHR groups at the wing-tip position, trends in Pd-Cl bond lengths reflecting similar trans influences of the particular carbene and phosphine donors, and the results from cyclic voltammetric measurements. Furthermore, the carbenes were used as defined (pre)catalysts in Miyaura borylation of aryl bromides with bis(pinacolato)diboron. When applying the optimized catalytic system (1 mol % Pd catalyst, KOAc as the base, 2-propanol, 85 °C), this reaction produced a range of simple and substituted arylboronate pinacol esters in high yield and without biaryl side products.

Stereochemical aspects of the 'tert-amino effect'. 2. Enantio- and diastereoselectivity in the synthesis of quinolines, pyrrolo[1,2-a]quinolines, and [1,4]oxazino[4,3-a]quinolines

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