35135-38-7 Usage
Description
1,4-Naphthalenedione, 2-hydroxy-3-iodo-, also known as iodo hydroxyquinone, is a chemical compound and a derivative of naphthoquinone. It is characterized by its light yellow to yellow-brown appearance and is primarily used in organic synthesis and as a pharmaceutical intermediate. Due to its potential harmful effects if ingested, inhaled, or comes into contact with the skin or eyes, it should be handled with caution. Its unique chemical properties and structure also make it a candidate for applications in material science and nanochemistry.
Uses
Used in Organic Synthesis:
1,4-Naphthalenedione, 2-hydroxy-3-iodois used as a key intermediate in the synthesis of various organic compounds, contributing to the formation of complex molecules and enhancing the diversity of chemical products.
Used in Pharmaceutical Industry:
1,4-Naphthalenedione, 2-hydroxy-3-iodoserves as a pharmaceutical intermediate, playing a crucial role in the development of new drugs and medicines. Its unique structure allows for the creation of novel therapeutic agents with potential applications in various medical fields.
Used in Dye and Pigment Manufacturing:
In the dye and pigment industry, 1,4-Naphthalenedione, 2-hydroxy-3-iodois utilized in the production of dyes and pigments, providing color and stability to various products, including textiles, plastics, and paints.
Used in Material Science:
1,4-Naphthalenedione, 2-hydroxy-3-iodohas potential applications in material science due to its unique chemical properties, which can be leveraged to develop new materials with enhanced properties, such as improved conductivity, stability, or reactivity.
Used in Nanochemistry:
1,4-Naphthalenedione, 2-hydroxy-3-iodo-'s structure and properties make it a promising candidate for nanochemistry applications, where it can be used to create nanoscale materials with specific functions, such as drug delivery systems, sensors, or catalysts.
Check Digit Verification of cas no
The CAS Registry Mumber 35135-38-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,1,3 and 5 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 35135-38:
(7*3)+(6*5)+(5*1)+(4*3)+(3*5)+(2*3)+(1*8)=97
97 % 10 = 7
So 35135-38-7 is a valid CAS Registry Number.
35135-38-7Relevant articles and documents
Lawsone, Juglone, and β-Lapachone Derivatives with Enhanced Mitochondrial-Based Toxicity
Anaissi-Afonso, Laura,Oramas-Royo, Sandra,Ayra-Plasencia, Jessel,Martín-Rodríguez, Patricia,García-Luis, Jonay,Lorenzo-Castrillejo, Isabel,Fernández-Pérez, Leandro,Estévez-Braun, Ana,Machín, Félix
, p. 1950 - 1957 (2018)
Naphthoquinones are among the most active natural products obtained from plants and microorganisms. Naphthoquinones exert their biological activities through pleiotropic mechanisms that include reactivity against cell nucleophiles, generation of reactive oxygen species (ROS), and inhibition of proteins. Here, we report a mechanistic antiproliferative study performed in the yeast Saccharomyces cerevisiae for several derivatives of three important natural naphthoquinones: lawsone, juglone, and β-lapachone. We have found that (i) the free hydroxyl group of lawsone and juglone modulates toxicity; (ii) lawsone and juglone derivatives differ in their mechanisms of action, with ROS generation being more important for the former; and (iii) a subset of derivatives possess the capability to disrupt mitochondrial function, with β-lapachones being the most potent compounds in this respect. In addition, we have cross-compared yeast results with antibacterial and antitumor activities. We discuss the relationship between the mechanistic findings, the antiproliferative activities, and the physicochemical properties of the naphthoquinones.
METHOD FOR PRODUCING 2-ALKYLCARBONYLNAPHTHO[2,3-b]FURAN-4,9-DIONE-RELATED SUBSTANCE, AND SAID RELATED SUBSTANCE
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Paragraph 0366-0368, (2019/03/08)
Provided is a method for producing a 2-alkylcarbonylnaphtho[2,3-b]furan-4,9-dione-related substance, which is suitable for the production on an industrial scale. The present invention provides: a method for producing an intermediate for the production of
1,4-Naphthoquinones potently inhibiting P2X7 receptor activity
Faria,Oliveira,Salles,Oliveira,von Ranke,Bello,Rodrigues,Castro,Louvis,Martins,Ferreira
, p. 1361 - 1372 (2017/11/17)
P2X7 receptor (P2X7R) is an ATP-gated ion-channel with potential therapeutic applications. In this study, we prepared and searched a series of 1,4-naphthoquinones derivatives to evaluate their antagonistic effect on both human and murine P2X7 receptors. W