357428-17-2

Basic information

• Product Name: (1S,2R)-N-(2-hydroxy-1-methyl-2-phenylethyl)-3,3-dimethoxypropanamide
• CAS NO: 357428-17-2
• Molecular Weight: 267.325
• Mol File: 357428-17-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1S,2R)-N-(2-hydroxy-1-methyl-2-phenylethyl)-3,3-dimethoxypropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2R)-N-(2-hydroxy-1-methyl-2-phenylethyl)-3,3-dimethoxypropanamide(357428-17-2)
• EPA Substance Registry System: (1S,2R)-N-(2-hydroxy-1-methyl-2-phenylethyl)-3,3-dimethoxypropanamide(357428-17-2)

Safety Data

• Hazardous Substances Data: 357428-17-2(Hazardous Substances Data)

Upstream product

• 7424-91-1 methyl 3,3-dimethoxypropionate 
• 492-41-1 (1R,2S)-norephedrine 

Relevant articles and documents

Structural features in the seven-membered vs. Fourteen-membered ring cyclization of hydroxyamido ketals derived from β-amino alcohols

Hydroxyamido ketals 1 and 3-12, prepared from β-amino alcohols, are obtained either as a single form with a trans (1 and 3-8) or cis (9) conformation in the R = H series or as two cis and trans rotamers in the R ≠ H series (10-12). - The cyclization of these compounds was studied under acidic conditions (PTSA) and over a well defined range of concentrations (c = 0.1-0.2 M). While cis amide 9 and mixtures of cis and trans rotamers 10-12 resulted practically exclusively in the formation of seven-membered ring lactams 22-25, trans compounds 1 and 3-8 afforded fourteen-membered ring bislactams 2, 13-18, the formation of which involves a dimerization. Macrocycles were obtained as three diastereomers in the chiral series 2, 13-16 and as two isomers in the achiral series 17 and 18. Nineteen macrocyclic bislactams have thus been synthesized.