3601-66-9

Basic information

• Product Name: TERT-BUTOXYCARBONYLAMINO-PHENYL-ACETIC ACID
• Synonyms: BOC-DL-PHG-OH;BOC-DL-(PHENYL)GLY-OH;TERT-BUTOXYCARBONYLAMINO-PHENYL-ACETIC ACID;RARECHEM AK ML 0503;N-TERT-BUTOXYCARBONYL-DL-PHENYLGLYCINE;N-ALPHA-T-BUTOXYCARBONYL-DL-PHENYLGLYCINE;N-BOC-DL-PHENYLGLYCINE;tert-Butoxycarbonylphenylglycine
• CAS NO: 3601-66-9
• Molecular Formula: C₁₃H₁₇NO₄
• Molecular Weight: 251.28
• EINECS: 1533716-785-6
• Product Categories: Amino Acids and Derivatives;Miscellaneous
• Mol File: 3601-66-9.mol
• Article Data: 32

Chemical Properties

• Melting Point: 111-112℃
• Boiling Point: 407.2±38.0 °C(Predicted)
• Appearance: /
• Density: 1.182±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 3.51±0.10(Predicted)
• CAS DataBase Reference: TERT-BUTOXYCARBONYLAMINO-PHENYL-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTOXYCARBONYLAMINO-PHENYL-ACETIC ACID(3601-66-9)
• EPA Substance Registry System: TERT-BUTOXYCARBONYLAMINO-PHENYL-ACETIC ACID(3601-66-9)

Safety Data

• Hazardous Substances Data: 3601-66-9(Hazardous Substances Data)

Usage

General Description

TERT-BUTOXYCARBONYLAMINO-PHENYL-ACETIC ACID, also known as Boc-Phg-OH, is a chemical compound commonly used in the field of organic chemistry as a protecting group for amines. It is an amino acid derivative with a tert-butoxycarbonyl (Boc) protecting group attached to the amino group and a phenylacetic acid moiety. TERT-BUTOXYCARBONYLAMINO-PHENYL-ACETIC ACID is often used in peptide synthesis to protect the amine functional group, allowing for selective reactions to occur at other parts of the peptide chain. The Boc-Phg-OH compound can be easily removed under mild acidic conditions, making it a valuable tool in the development of pharmaceuticals and bioactive peptides.

Upstream product

• 941602-11-5 tert-butyl N-(2-nitro-1-phenylethyl)carbamate 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 4248-19-5 tert-butyl carbazate 
• 124-38-9 carbon dioxide 
• 100-52-7 benzaldehyde 
• 155396-71-7 tert-butyl N-(phenyl(phenylsulfonyl)methyl)carbamate 
• 1273585-69-5 (butyl)3SnCH(phenyl)NH(tert-butoxycarbonyl) 
• 150884-50-7 benzaldehyde N-boc imine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 15028-39-4 L-2-phenylglycine methyl ester hydrochloride 
• 117049-13-5 tert-Butoxycarbonylamino-phenyl-acetic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 
• 117049-08-8 (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl<(tert-butoxycarbonyl)amino>bromoacetate 
• 117681-86-4 (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (tert-butoxycarbonyl)aminoacetate 
• 4530-20-5 BOC-glycine 

Downstream Products

• 672960-95-1 tert-butyl [1-(2,5-dimethylphenylcarbamoyl)-1-phenyl-methyl]-carbamate 
• 672960-59-7 tert-butyl [1-(4-chlorophenylcarbamoyl)-1-phenyl-methyl]-carbamate 
• 499782-16-0 tert-butyl [1-(phenylcarbamoyl)-1-phenyl-methyl]-carbamate 
• 672962-12-8 tert-butyl [1-(4-isopropylphenylcarbamoyl)-1-phenyl-methyl]-carbamate 
• 672960-39-3 tert-butyl [1-(2-methoxyhenylcarbamoyl)-1-phenyl-methyl]-carbamate 
• 1021948-09-3 D,L-N-Boc-Phg-SEt 
• 929016-23-9 1,1-dimethylethyl-{2-[2-(5-bromo-2-cyano-4-pyrimidinyl)-2-(2-methylpropyl)hydrazino]-2-oxo-1-phenylethyl}carbamate 
• 169512-94-1 (+/-)-N-tert-butoxycarbonyl-α-phenylglycine methyl ester 
• 141190-94-5 (R)-N-(tert-butoxycarbonyl)phenylglycine methyl ester 
• 143978-88-5 N-tert-butoxycarbonyl-L-phenylglycine methyl ester 
• 35264-05-2 2-((tert-butoxycarbonyl)amino)-2-cyclohexylacetic acid 
• 890524-38-6 C₂₃H₂₇N₃O₅ 
• 879502-67-7 2-(S)-(2-tert-butoxycarbonylamino-2-phenylacetylamino)-3-phenylpropionic acid ethyl ester 
• 890524-27-3 C₂₀H₂₁N₃O₃ 

Relevant articles and documents

Synthesis ofN-Boc-α-amino Acids from Carbon Dioxide by Electrochemical Carboxylation ofN-Boc-α-aminosulfones

Electrochemical reduction ofN-Boc-α-aminosulfones in DMF using an undivided cell equipped with a Pt plate cathode and an Mg rod anode under atmospheric pressure of bubbling carbon dioxide through the solution under constant current conditions resulted in a reductive C-S bond cleavage with elimination of benzenesulfinate ion generating the corresponding anion species followed by fixation of carbon dioxide to give the correspondingN-Boc-α-amino acids in moderate to good yields.

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