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361193-21-7

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361193-21-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 361193-21-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,6,1,1,9 and 3 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 361193-21:
(8*3)+(7*6)+(6*1)+(5*1)+(4*9)+(3*3)+(2*2)+(1*1)=127
127 % 10 = 7
So 361193-21-7 is a valid CAS Registry Number.

361193-21-7Relevant articles and documents

Synthesis and structure-activity relationships of 3,4,5-trisubstituted-1,2,4-triazoles: High affinity and selective somatostatin receptor-4 agonists for Alzheimer's disease treatment

Crider, A. Michael,Farr, Susan A.,Frare, Rafael,Hospital, Audrey,Kontoyianni, Maria,Kukielski, Stephen G.,Minaeian, Mahsa,Mobayen, Shirin,Neumann, William L.,Niehoff, Michael L.,Sandoval, Karin E.,Slater, Olivia,Srabony, Khush N.,Witt, Ken A.

supporting information, p. 1352 - 1365 (2021/11/09)

Somatostatin receptor-4 (SST4) is highly expressed in brain regions affiliated with learning and memory. SST4 agonist treatment may act to mitigate Alzheimer's disease (AD) pathology. An integrated approach to SST4 agonist lead optimization is presented herein. High affinity and selective agonists with biological efficacy were identified through iterative cycles of a structure-based design strategy encompassing computational methods, chemistry, and preclinical pharmacology. 1,2,4-Triazole derivatives of our previously reported hit (4) showed enhanced SST4 binding affinity, activity, and selectivity. Thirty-five compounds showed low nanomolar range SST4 binding affinity, 12 having a Ki 500-fold affinity for SST4 as compared to SST2A. SST4 activities were consistent with the respective SST4 binding affinities (EC50 600-fold selectivity over SST2A) display a favorable physiochemical profile, and was advanced to learning and memory behavior evaluations in the senescence accelerated mouse-prone 8 model of AD-related cognitive decline. Chronic administration enhanced learning with i.p. dosing (1 mg kg-1) compared to vehicle. Chronic administration enhanced memory with both i.p. (0.01, 0.1, 1 mg kg-1) and oral (0.01, 10 mg kg-1) dosing compared to vehicle. This study identified a novel series of SST4 agonists with high affinity, selectivity, and biological activity that may be useful in the treatment of AD. This journal is

Identification and development of 2,5-disubstituted oxadiazole as potential candidate for treatment of XDR and MDR tuberculosis

Bakal, Ravi L.,Gattani, Surendra G.

scheme or table, p. 278 - 282 (2012/03/08)

Tuberculosis, the infection on the verge of eradication once, is now a great threat to mankind. Emergence of MDR and XDR-TB synergised with HIV and other immune-compressive diseases have increased the life threatening capacities of the disease. A small mo

Synthesis and SAR evaluation of 1,2,4-triazoles as A2A receptor antagonists

Alanine, Alexander,Anselm, Lilli,Steward, Lucinda,Thomi, Stefan,Vifian, Walter,Groaning, Michael D.

, p. 817 - 821 (2007/10/03)

The synthesis and in vitro structure-activity relationships (SAR) of a series of triazoles as A2A receptor antagonists is reported. This resulted in the identification of potent, selective and permeable 1,2,4-triazoles such as 42 for further op

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