36600-75-6Relevant articles and documents
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Bell,R.P.,Grainger,S.
, p. 1367 - 1370 (1976)
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Discovery of remogliflozin etabonate: A potent and highly selective SGLT2 inhibitor
Shimizu, Kazuo,Fujikura, Hideki,Fushimi, Nobuhiko,Nishimura, Toshihiro,Tatani, Kazuya,Katsuno, Kenji,Fujimori, Yoshikazu,Watanabe, Shinjiro,Hiratochi, Masahiro,Nakabayashi, Takeshi,Kamada, Noboru,Arakawa, Koichi,Hikawa, Hidemasa,Azumaya, Isao,Isaji, Masayuki
, (2021/02/16)
We optimized the structure of an active metabolite (1) of WAY-123783, which was obtained from mouse urine after oral administration, to improve selectivity for SGLT2 and oral bioavailability. O-glucoside derivative 24 (remogliflozin etabonate) was subsequently identified as a potent, highly selective, and orally available SGLT2 inhibitor.
Preparation method of 4-p-hydroxyphenyl-2-butanone
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, (2019/02/10)
The invention discloses a preparation method of 4-p-hydroxyphenyl-2-butanone. The preparation method comprises the following steps of using anisaldehyde from a natural source as a raw material, preparing to obtain anisalcohol through a reduction reaction, preparing to obtain p-methoxybenzyl chloride through a chlorination reaction, next preparing to obtain 2-acetyl-3-(4-methoxyphenyl)ethyl propionate through a substitution reaction with ethyl acetoacetate from a biomass source, next preparing to obtain 4-(4-methoxyphenyl)-2-butanone through hydrolysis and decarboxylation reactions, and finallypreparing to obtain the 4-p-hydroxyphenyl-2-butanone through a demethylation reaction. The preparation method can be used for realizing the preparation of all-natural carbon-source raspberry ketone,and has the advantages of being simple and direct in route, easy to operate, environmentally friendly and high in yield and the like.