37127-98-3

Basic information

• Product Name: 4-benzyl-5-methyl-2-(p-tolyl)-2,3-dihydro-4H-1,4-thiazin-3-one
• Synonyms: 4-benzyl-5-methyl-2-(p-tolyl)-2,3-dihydro-4H-1,4-thiazin-3-one
• CAS NO: 37127-98-3
• Molecular Weight: 309.432
• Mol File: 37127-98-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-benzyl-5-methyl-2-(p-tolyl)-2,3-dihydro-4H-1,4-thiazin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-benzyl-5-methyl-2-(p-tolyl)-2,3-dihydro-4H-1,4-thiazin-3-one(37127-98-3)
• EPA Substance Registry System: 4-benzyl-5-methyl-2-(p-tolyl)-2,3-dihydro-4H-1,4-thiazin-3-one(37127-98-3)

Safety Data

• Hazardous Substances Data: 37127-98-3(Hazardous Substances Data)

Upstream product

• 2942-54-3 diethyl (4-methylbenzoyl)phosphonate 
• 4209-18-1 3-(1-phenylmethyl)-4-methylthiazol-3-ium chloride 
• 100-39-0 benzyl bromide 
• 3457-48-5 1,2-di(4-methylphenyl)-1,2-ethanedione 
• 4356-66-5 3-Benzyl-4-methylthiazolium bromide 

Relevant articles and documents

Unexpected reactivity of diaryl α-diketones with thiazolium carbenes: Discovery of a novel multicomponent reaction for the facile synthesis of 1,4-thiazin-3-ones

Diaryl α-diketones do not undergo polarity reversal in the presence of (benzo)thiazolium carbenes but are engaged in a novel multicomponent reaction with water to efficiently give medicinally relevant 1,4-thiazin-3-one heterocycles. Three different sets of conditions have been optimized to furnish the title compounds in fair to excellent yields depending on the electronic properties of α-diketone aromatic substituents and thiazolium or benzothiazolium substrate. A plausible reaction mechanism is also proposed based on the isolation and characterization of the postulated key intermediate and isotopic labeling experiments.