375346-05-7Relevant articles and documents
METHOD OF SYNTHESIZING CAMPTOTHECIN-RELATING COMPOUNDS
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Page 38, (2010/02/05)
The present invention is to prepare efficiently 2'-amino-5'-hydroxypropiophenone corresponding to the AB-ring part of camptothecin (CPT) skeleton and a tricyclic ketone corresponding to the CDE-ring part in order to provide efficiently CPT by the total synthesis, which is a starting material for irinotecan hydrochloride and various kinds of camptothecin derivatives, and to provide stably CPT and its derivatives.
Catalytic enantioselective synthesis of (20s)-camptothecin intermediates using cyanosilylation of ketones promoted by D-glucose-derived lanthanide catalyst
Yabu, Kazuo,Masumoto, Shuji,Kanai, Motomu,Du, Wu,Curran, Dennis P.,Shibasaki, Masakatsu
, p. 369 - 385 (2007/10/03)
An efficient catalytic enantioselective synthetic route was developed for Curran's versatile camptothecin intermediate (5). The key step is the catalytic enantioselective cyanosilylation of ketone (7) using a chiral samarium (Sm) complex. The target ketone cyanohydrin (6) was obtained with 90% ee using 2 mol % of the catalyst. A gadolinium (Gd) complex derived from the same chiral ligand could also be used as an enantioselective catalyst to synthesize Corey's intermediate (11).
Solution-phase preparation of a 560-compound library of individual pure mappicine analogues by fluorous mixture synthesis
Zhang, Wei,Luo, Zhiyong,Chen, Christine Hiu-Tung,Curran, Dennis P.
, p. 10443 - 10450 (2007/10/03)
Solution-phase mixture synthesis has efficiency advantages and favorable reaction kinetics. Applications of this technique, however, have been discouraged by the difficulty in obtaining individual, pure final products by using conventional separation and
