376348-75-3

Basic information

• Product Name: Cyclohexanecarbonyl chloride, 4,4-difluoro- (9CI)
• Synonyms: Cyclohexanecarbonyl chloride, 4,4-difluoro- (9CI);4,4-Difluorocyclohexanecarbonyl chloride;4,4-DIFLUOROCYCLOHEXANE-1-CARBONYL CHLORIDE(WXG02010)
• CAS NO: 376348-75-3
• Molecular Formula: C₇H₉ClF₂O
• Molecular Weight: 182.5955664
• Product Categories: ACIDHALIDE
• Mol File: 376348-75-3.mol
• Article Data: 25

Chemical Properties

• Boiling Point: 185.311°C at 760 mmHg
• Flash Point: 65.874°C
• Appearance: /
• Density: 1.25g/cm³
• Vapor Pressure: 0.702mmHg at 25°C
• Refractive Index: 1.428
• CAS DataBase Reference: Cyclohexanecarbonyl chloride, 4,4-difluoro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanecarbonyl chloride, 4,4-difluoro- (9CI)(376348-75-3)
• EPA Substance Registry System: Cyclohexanecarbonyl chloride, 4,4-difluoro- (9CI)(376348-75-3)

Safety Data

• Hazardous Substances Data: 376348-75-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H9ClF2O/c8-6(11)5-1-3-7(9,10)4-2-5/h5H,1-4H2

Upstream product

• 122665-97-8 4,4-difluorocyclohexanecarboxylic acid 
• 7719-09-7 thionyl chloride 
• 17159-79-4 ethyl 4-oxocyclohexane-1-carboxylate 
• 178312-47-5 ethyl 4,4-difluorocyclohexane-1-carboxylate 

Downstream Products

• 889673-93-2 1-(4,4-difluorocyclohexanecarbonylamino)-1-phenyl-ethene 
• 889674-03-7 C₂₂H₂₅F₄NO₂ 
• 376348-65-1 4,4-difluoro-N-[(1S)-3-[(1R,5S)-3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]cyclohexane-1-carboxamide 
• 376348-76-4 ethyl (S)-3-[(4,4-difluorocyclohexyl)carboxamido]-3-phenylpropanoate 
• 376348-65-1 maraviroc 
• 376348-77-5 (S)-4,4-difluoro-N-(3-hydroxy-1-phenylpropyl)cyclohexanecarboxamide 
• 376348-78-6 4,4-difluorocyclohexanecarboxylic acid (3-oxo-1-phenyl-propyl)-amide 

Relevant articles and documents

A novel and efficient asymmetric synthesis of anti-HIV drug maraviroc

A novel and efficient route to asymmetric synthesis of Maraviroc by using (S)-tert-butanesulfinamide as chiral auxiliary is described. Two interesting impurities of the process are isolated and identified. The synthesis was concise, mild, and easy to oper

Preparation method of

The preparation method comprises the following steps: taking a halogen-containing azide compound as a raw material in γ-position, carrying out a reaction, and preparing and a derivative thereof. The method is characterized in γ-position halogen-containing azide compound as a raw material and is subjected to reduction. A series of non-sequential reactions, such as hydrolysis, substitution, condensation, reductive amination, and the like. A target compound, that is, a Mahalanobis derivative, can be obtained. The preparation method has the advantages of mild reaction conditions, simplicity and convenience in operation, low cost, less side reaction, high product purity, simplicity and convenience in separation and purification and the like. The invention further provides the pulvernolol and derivatives thereof prepared by the method and application thereof.

Visible-Light-Assisted Gold-Catalyzed Fluoroarylation of Allenoates

A strategically novel synthetic method for the fluoroarylation of allenic ester was developed that enables the expedient construction of a host of β-fluoroalkyl-containing cinnamate derivatives. The reaction proceeds through visible-light-promoted gold redox catalysis, occurs smoothly under very mild reaction conditions, accommodates a large variety of functional groups, and more importantly allows the incorporation of fluorine and aryl groups with excellent regio- and stereoselectivity. The concomitant activation mode for both the allene motif and the hydrogen fluoride is key for the success of the reaction.