378749-99-6Relevant articles and documents
Synthesis of (3R,5S)-5-hydroxy-de-O-methyllasiodiplodin: A facile and stereoselective approach
Bujaranipalli, Sheshurao,Das, Saibal
, p. 3747 - 3749 (2015/06/08)
A concise and facile synthesis of (3R,5S)-5-hydroxy-de-O-methyllasiodiplodin has been demonstrated in 12 steps starting from methylacetoacetate and (±)propylene oxide. The key reactions involved are Jacobsen's hydrolytic kinetic resolution, Sharpless asymmetric epoxidation, Mitsunobu, and ring closing metathesis reaction for the construction of macrolactone with two chiral substitutions on it.
Novel macrocycles and uses thereof
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, (2008/06/13)
The present invention relates to compounds having the structure (I) (and pharmaceutically acceptable derivatives thereof) wherein R1-R4, Z, X, A-B, D-E, G-J, and K-L are as defined herein, the synthesis thereof and the use of these c