38048-32-7 Usage
Description
S-(4-Nitrobenzyl)-6-thioinosine (NBTI) is a nucleoside analog that belongs to the family of S6-substituted 6-thiopurine nucleosides. It is an off-white solid and functions as a ligand of adenosine transporter, regulating nucleoside transport mechanisms in animals. NBTI also acts as a covalent photoaffinity probe for nucleoside transport and has binding sites located on brain capillaries.
Uses
Used in Pharmaceutical Research:
S-(4-Nitrobenzyl)-6-thioinosine is used as a prototype inhibitor for the human equilibrative nucleoside transporter (hENT1) with a high affinity ligand Kd of 0.1-1.0 nM. It is employed in the investigation of anticancer, antiviral, cardioprotective, and neuroprotective agents due to its role as a nucleoside transporter inhibitor.
Used in Anticancer Applications:
In the pharmaceutical industry, S-(4-Nitrobenzyl)-6-thioinosine is used as an inhibitor of hENT1 for studying the potential therapeutic applications in cancer treatment. Its ability to inhibit nucleoside transport can provide insights into the development of novel anticancer drugs.
Used in Antiviral Applications:
S-(4-Nitrobenzyl)-6-thioinosine is also used as a nucleoside transporter inhibitor in the development of antiviral drugs. By understanding its interaction with hENT1, researchers can explore new strategies to combat viral infections.
Used in Cardioprotective Applications:
In the field of cardiology, S-(4-Nitrobenzyl)-6-thioinosine serves as a research tool to investigate the role of nucleoside transport in heart protection and potential cardioprotective therapies.
Used in Neuroprotective Applications:
NBTI is utilized in neuroscience research to study the role of nucleoside transport in neuroprotection and the development of therapies for neurological disorders.
Used in Drug Delivery Systems:
S-(4-Nitrobenzyl)-6-thioinosine can be employed in the development of drug delivery systems, particularly for targeting the brain capillaries, due to its binding affinity to these sites. This application can be useful in enhancing the delivery and bioavailability of various therapeutic agents.
Biological Activity
Equilibrative nucleoside transporter 1 (ENT1) inhibitor (K i values are 0.4 and 2800 nM for hENT1 and hENT2 respectively).
Biochem/physiol Actions
Inhibitor of equilibrative nucleoside transporters (ENTs), particularly adenosine transporters, in central nervous system and vascular smooth muscle.
Check Digit Verification of cas no
The CAS Registry Mumber 38048-32-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,0,4 and 8 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 38048-32:
(7*3)+(6*8)+(5*0)+(4*4)+(3*8)+(2*3)+(1*2)=117
117 % 10 = 7
So 38048-32-7 is a valid CAS Registry Number.
38048-32-7Relevant articles and documents
Microwave-promoted "one-Pot" synthesis of 4- nitrobenzylthioinosine analogues using thiourea as a sulfur precursor
Niu, Hong-Ying,Xia, Chao,Qu, Gui-Rong,Wu, Shan,Jiang, Yi,Jin, Xin,Guo, Hai-Ming
supporting information; experimental part, p. 45 - 49 (2012/04/04)
An efficient one-pot method for the synthesis of various C6-alkylthio-substituted purine nucleosides has been developed under microwave irradiation with good to excellent yields without any metal catalyst (see scheme). This process expands the scope of existing synthetic methodologies and was further successfully applied for synthesis of the biologically important compound 4-nitrobenzylthioinosine (NBTI).
