39652-02-3Relevant articles and documents
The Anticancer Activity of Organotelluranes: Potential Role in Integrin Inactivation
Silberman, Alon,Kalechman, Yona,Hirsch, Shira,Erlich, Ziv,Sredni, Benjamin,Albeck, Amnon
, p. 918 - 927 (2016)
Organic TeIV compounds (organotelluranes) differing in their labile ligands exhibited anti-integrin activities in vitro and anti-metastatic properties in vivo. They underwent ligand substitution with l-cysteine, as a thiol model compound. Unlike inorganic TeIV compounds, the organotelluranes did not form a stable complex with cysteine, but rather immediately oxidized it. The organotelluranes inhibited integrin functions, such as adhesion, migration, and metalloproteinase secretion mediation in B16F10 murine melanoma cells. In comparison, a reduced derivative with no labile ligand inhibited adhesion of B16F10 cells to a significantly lower extent, thus pointing to the importance of the labile ligands of the TeIV atom. One of the organotelluranes inhibited circulating cancer cells in vivo, possibly by integrin inhibition. Our results extend the current knowledge on the reactivity and mechanism of organotelluranes with different labile ligands and highlight their clinical potential.
Cyclofunctionalization of Hydroxyolefins Induced by Arenetellurinyl Acetate
Hu, Nan Xing,Aso, Yoshio,Otsubo, Tetsuo,Ogura, Fumio
, p. 4391 - 4397 (2007/10/02)
Treatment of arenetellurinic anhydride (1) with acetic acid or anhydride readily formed arenetellurinyl acetate (2).It underwent not only oxytellurinylation of an olefin but also intramolecular cyclofunctionalization of various hydroxyolefins to cyclic ethers.The latter reaction was effectively accelerated by addition of boron trifluoride etherate or tin(IV) chloride and highly regio- and stereoselective.The tellurium functional group introduced in the cyclic ethers could be manipulated into other versatile groups by telluroxide elimination, halogenolysis, and reductive detelluration.
SECONDARY BONDING. PART 13. ARYL-TELLURIUM(IV) AND -IODINE(III) ACETATES AND TRIFLUOROACETATES. THE CRYSTAL AND MOLECULAR STRUCTURES OF BIS-(p-METHOXYPHENYL)TELLURIUM DIACETATE, μ-OXO-BIS HYDRATE, AND BENZENE
Alcock, Nathaniel W.,Harrison, W. David,Howes, Colin
, p. 1709 - 1716 (2007/10/02)
The crystal and molecular structures of the title compounds have been determined from diffractometer data by the heavy-atom method, and their preparations are described.Crystals of (p-MeOC6H4)2Te(O2CMe)2 (1) are monoclinic, space group P21/c, with unit-cell dimensions a = 9.529(2), b = 11.984(2), c = 17.035(2) Angstroem, β = 101.70(2) deg, Z = 4, and for 3033 observed reflections (I/?(I) > 3.0), R = 0.022.Crystals of 2O >2*H2O (2) are triclinic, space group , with unit-cell dimensions a = 13.988(3), b= 14.287(3), c = 15.689(3) Angstroem, α = 80.40(2), β = 81.89(2), γ = 86.65(2) deg, Z = 2, and for 5290 observed reflections, R = 0.042.Crystals of PhI(O2CCF3)2 (3) are triclinic, spacegroup , with unit-cell dimensions a = 9.787(4), b= 9.055(3), c = 7.674(3) Angstroem, α = 91.45(3), β = 99.78(3), γ = 89.21(3) deg, Z = 2, and for 2104 observed reflections, R = 0.037.All three compounds have pseudo-trigonal-bipyramidal primary geometry , and form secondary bonds to give pentagonal planar systems around Te and I, also with linear C-Te...O systems.In the light of these results, previously published tellurium nitrate structures are re-interpreted.
