397864-40-3
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Basic information
- Product Name: 6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid
- Synonyms: 6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid
- CAS NO:397864-40-3
- Molecular Formula:
- Molecular Weight: 506.568
- EINECS: N/A
- Product Categories: N/A
- Mol File: 397864-40-3.mol
- Article Data: 0
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Chemical Properties
- Melting Point: >154°C (dec.)
- Boiling Point: 622.1±55.0 °C(Predicted)
- Flash Point: N/A
- Appearance: N/A
- Density: 1.38±0.1 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: 6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid(CAS DataBase Reference)
- NIST Chemistry Reference: 6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid(397864-40-3)
- EPA Substance Registry System: 6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid(397864-40-3)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 397864-40-3(Hazardous Substances Data)
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397864-40-3 Usage
Description
6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid is a complex steroid compound characterized by its unique molecular structure. It is a derivative of androstane, featuring a 3-oxo group, a 17β-carbothioic acid functional group, and various fluoro and hydroxy substitutions. This molecule is known for its potential therapeutic applications, particularly in the field of anti-inflammatory medications.Uses
Used in Pharmaceutical Industry:6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid is used as an intermediate compound for the synthesis of fluticasone furoate (I), a therapeutically useful anti-inflammatory corticosteroid. Fluticasone furoate is widely utilized in the treatment of various inflammatory conditions, such as asthma, chronic obstructive pulmonary disease (COPD), and allergic rhinitis, due to its potent anti-inflammatory and immunosuppressive properties.
Used in Research and Development:
This steroid compound is also used as an impurity reference material in the development and quality control of fluticasone furoate and its solvates. The presence of this impurity in the final product can be monitored and controlled to ensure the safety and efficacy of the medication.
Used in the Preparation of Crystalline Forms:
6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid is employed in the preparation of crystalline forms of fluticasone furoate. These crystalline forms are essential for the development of stable and effective drug formulations, as they can influence the drug's solubility, stability, and bioavailability.
Check Digit Verification of cas no
The CAS Registry Mumber 397864-40-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,9,7,8,6 and 4 respectively; the second part has 2 digits, 4 and 0 respectively.Calculate Digit Verification of CAS Registry Number 397864-40:
(8*3)+(7*9)+(6*7)+(5*8)+(4*6)+(3*4)+(2*4)+(1*0)=213
213 % 10 = 3
So 397864-40-3 is a valid CAS Registry Number.
397864-40-3Upstream product
397864-40-3Downstream Products
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6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid
