401792-02-7Relevant articles and documents
Novel 2-Substituted 3-Hydroxy-1,6-dimethylpyridin-4(1 H)-ones as Dual-Acting Biofilm Inhibitors of Pseudomonas aeruginosa
Liu, Jun,Hou, Jin-Song,Li, Yi-Bin,Miao, Zhi-Ying,Sun, Ping-Hua,Lin, Jing,Chen, Wei-Min
, p. 10921 - 10945 (2020/11/09)
2-Heptyl-3-hydroxy-4(1H)-quinolone (PQS), a compound from P. aeruginosa, functions as both a quorum sensing (QS) regulator and a potent iron chelator to induce expression of pyoverdine and pyochelin which are involved in high-affinity iron transport syste
Novel hydroxypyridinone compounds as well as preparation method and application thereof
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, (2018/07/30)
The invention belongs to the field of medicines and discloses novel hydroxypyridinone compounds as well as a preparation method and an application thereof. The compounds have the chemical structure shown in a formula (I), (II) or (III), wherein R1 is prop
Synthesis, iron(III)-binding affinity and in vitro evaluation of 3-hydroxypyridin-4-one hexadentate ligands as potential antimicrobial agents
Xu, Bo,Kong, Xiao-Le,Zhou, Tao,Qiu, Di-Hong,Chen, Yu-Lin,Liu, Mu-Song,Yang, Rong-Hua,Hider, Robert C.
scheme or table, p. 6376 - 6380 (2011/12/02)
Iron is a critical element for the survival of bacteria. We have designed and synthesized two novel 3-hydroxypyridin-4-one hexadentate ligands with high affinity for iron(III), which disrupt bacterial iron absorption. Biological studies demonstrate that these two chelators have significant inhibitory effect against both Gram-positive and Gram-negative bacteria, and therefore have potential as antimicrobial agents.