40240-12-8Relevant articles and documents
Trans-3-Hydroxy-4-morpholinopiperidine - The pH-triggered conformational switch with a double flip
Samoshin, Andrey V.,Joo, Hyun,Korneichuk, Andrei Ya,Veselov, Ivan S.,Grishina, Galina V.,Samoshin, Vyacheslav V.
, p. 1020 - 1024 (2013)
Derivatives of trans-3-hydroxy-4-aminopiperidine are suggested as potential pH-sensitive conformational switches able to perform two consecutive flips (or flip-flop) when basicity/acidity of solution changes. Such a double switch of conformation was detected by 1H NMR for a model compound - trans-3-hydroxy-4-morpholinopiperidine. A combination of hydrogen bonding and electrostatic/dipole-dipole interactions was suggested for rationalization. Computational studies provided additional insight into the complex intra- and intermolecular forces that determine the relative stabilities of conformers. In similar structures an incorporated trans-3-hydroxy-4-aminopiperidine moiety can serve as a conformational pH-trigger when equipped with substituents designed to perform certain geometry-dependent functions, for example, as cation chelators or as lipid tails.
-
Princet, Bruno,Anselme, Gilles,Pornet, Jacques
, p. 34 - 40 (1999)
The 3,3-bis(trimethylsilyl)propene reacts with iminium ions (generated in situ from primary amines) by an aminomethylation-desilylation process and a subsequent cyclization, leading to N-alkyl-1,2,3,6-tetrahydropyridines as principal products. Tetrahydro-1,3-oxazines with a bis(trimethylsilyl)methyl group may also be observed. When primary amines with a tertiary group are used, the reaction leads only to ω-aminovinylsilanes, the steric hindrance inhibiting the progression of the reaction.
PRMT5 INHIBITORS
-
, (2021/06/26)
The present invention provides a compound selected from: compounds A, B, C, D and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are PRMT5 inhibitors. Also provided are methods of making compounds disclosed herein, pharmaceutic
ENANTIOMERIC COMPOUNDS
-
, (2020/05/07)
The present invention relates to enantiomeric compounds, their use in stereospecific reactions and to a method of preparing enantiomeric compounds.
A comparison between KbH4 and NaBH4 in their reduction of pyridinium salts
Quan, Hao,Zhu, Bin,Li, Xiaolin,Zhan, Li,Luo, Yu
, p. 1244 - 1250 (2019/12/23)
This paper compares potassium borohydride and sodium borohydride in the reduction of pyridinium salts to tetrahydropyridines. The results indicate that potassium borohydride is more suitable for this reaction with low costs, mild reaction conditions and i