403-46-3

Basic information

• Product Name: 4-FLUORO-N,N-DIMETHYLANILINE
• Synonyms: 4-FLUORO-N,N-DIMETHYLANILINE;N,N-DIMETHYL-4-FLUOROANILINE;(4-Fluoro-phenyl)-dimethyl-amine;Benzenamine,4-fluoro-N,N-dimethyl-;fluorodimethylaniline;p-Fluoro-N,N-dimethylaniline;NISTC403463;4-FLUORO-N,N-DIMETHYLANILINE 98+%
• CAS NO: 403-46-3
• Molecular Formula: C₈H₁₀FN
• Molecular Weight: 139.17
• Mol File: 403-46-3.mol
• Article Data: 56

Chemical Properties

• Melting Point: 36 °C
• Boiling Point: 200 °C
• Flash Point: 67.5 °C
• Appearance: /
• Density: 1.057 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-FLUORO-N,N-DIMETHYLANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO-N,N-DIMETHYLANILINE(403-46-3)
• EPA Substance Registry System: 4-FLUORO-N,N-DIMETHYLANILINE(403-46-3)

Safety Data

• Hazardous Substances Data: 403-46-3(Hazardous Substances Data)

Usage

General Description

4-FLUORO-N,N-DIMETHYLANILINE is a chemical compound with the molecular formula C8H10FN. It is characterized by the presence of a fluorine atom, two methyl groups, and an aniline moiety. 4-FLUORO-N,N-DIMETHYLANILINE is commonly used as an intermediate for the synthesis of various pharmaceuticals, dyes, and agrochemicals. It is also used as a reagent in organic chemical reactions. 4-FLUORO-N,N-DIMETHYLANILINE is a colorless to pale yellow liquid at room temperature and has a slightly sweet odor. It is important to handle this compound with caution, as it may be harmful if ingested, inhaled, or absorbed through the skin.

Upstream product

• 64-18-6 formic acid 
• 459-59-6 4-fluoro-N-methylaniline 
• 50-00-0 formaldehyd 
• 455-08-3 p-FC₆H₄NMe₃(+)*I(-) 
• 130445-20-4 4-Fluoro-N,N-dimethylaniline N-oxide 
• 67-56-1 methanol 
• 350-46-9 4-Fluoronitrobenzene 
• 124-38-9 carbon dioxide 
• 371-40-4 4-fluoroaniline 
• 616-38-6 carbonic acid dimethyl ester 
• 67-68-5 dimethyl sulfoxide 
• 121-69-7 N,N-dimethyl-aniline 
• 352-33-0 1-Chloro-4-fluorobenzene 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 329-09-9 4-fluoro-tri-N-methyl-anilinium; methyl sulfate 
• 333725-83-0 N-{2-[(2-dimethylamino-5-fluoro-phenyl)-(pyridin-2-ylamino)-methyl]-4-fluoro-phenyl}-N-methyl-formamide 
• 773-91-1 5-fluoro-1-methylisatin 
• 121-69-7 N,N-dimethyl-aniline 
• 1097200-06-0 4-(2-ethoxy-2-methoxyethyl)-N,N-dimethylaniline 
• 1346855-06-8 1-(2-(dimethylamino)-5-fluorophenyl)naphthalene-2-ol 
• 864910-76-9 2-((4-fluorophenyl)(methyl)amino)acetonitrile 
• 1621107-03-6 methyl 2-((4-fluorophenyl)(methyl)amino)benzoate 

Relevant articles and documents

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CO2-tuned highly selective reduction of formamides to the corresponding methylamines

We herein describe an efficient, CO2-tuned and highly selective C-O bond cleavage of N-methylated formanilides. With easy-to-handle and commercially available NaBH4 as the reductant, a variety of formanilides could be turned into the desired tertiary amines in moderate to excellent yields. The role of CO2 has been investigated in detail, and the mechanism is proposed on the basis of experiments.

Fe(III)-catalyzed Oxidative Povarov Reaction with Molecular Oxygen Oxidant

The synthesis of tetrahydroquinoline derivatives from dimethyl anilines and enamides has been developed by Fe(III)-phenanthroline complex under aerobic condition. The oxidation of tertiary anilines involving a single electron transfer of Fe(phen)3(PF6)3 afforded the iminium ion intermediate, which reacted with electron-rich alkenes to build a six-membered N-heterocycles containing quaternary carbon center via the oxidative Povarov reaction process.