4038-13-5

Basic information

• Product Name: 2,5-Dimethoxybenzophenone
• Synonyms: 2,5-Dimethoxybenzophenone;(2,5-Dimethoxy-phenyl)-phenyl-methanone
• CAS NO: 4038-13-5
• Molecular Formula: C₁₅H₁₄O₃
• Molecular Weight: 242.2699
• Mol File: 4038-13-5.mol
• Article Data: 29

Chemical Properties

• Melting Point: 51°C
• Boiling Point: 409.9°Cat760mmHg
• Flash Point: 193.4°C
• Appearance: /
• Density: 1.123g/cm³
• Vapor Pressure: 6.25E-07mmHg at 25°C
• Refractive Index: 1.557
• CAS DataBase Reference: 2,5-Dimethoxybenzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Dimethoxybenzophenone(4038-13-5)
• EPA Substance Registry System: 2,5-Dimethoxybenzophenone(4038-13-5)

Safety Data

• Hazardous Substances Data: 4038-13-5(Hazardous Substances Data)

Usage

Preparation

Obtained by reaction of benzoyl chloride with 1,4-dimethoxybenzene in methylene –chloride in the presence of stannic chloride at 0° (82%).

InChI:InChI=1/C15H14O3/c1-17-12-8-9-14(18-2)13(10-12)15(16)11-6-4-3-5-7-11/h3-10H,1-2H3

Upstream product

• 98-88-4 benzoyl chloride 
• 150-78-7 1,4-dimethoxybezene 
• 14770-96-8 oxybenzone 
• 77-78-1 dimethyl sulfate 
• 5005-35-6 2-pyridyl benzoate 
• 98635-85-9 (2,5-dimethoxyphenyl)(phenyl)methanol 
• 201230-82-2 carbon monoxide 
• 71-43-2 benzene 
• 38447-68-6 phenyl selenobenzoate 
• 93-97-0 benzoic acid anhydride 
• 574-66-3 Benzophenone oxime 
• 65-85-0 benzoic acid 
• 100-58-3 phenylmagnesium bromide 
• 93-02-7 2,5-dimethoxybenzaldehyde 

Downstream Products

• 36041-39-1 2-benzoyl-1,4-benzoquinone 
• 65-85-0 benzoic acid 
• 858786-38-6 3-(2,5-dimethoxy-phenyl)-3-hydroxy-2,3-diphenyl-propionic acid 
• 1381865-34-4 C₂₁H₂₆O₂ 
• 1381864-84-1 C₂₀H₂₆O₂ 
• 1381864-86-3 C₁₈H₂₂O₂ 
• 1381864-82-9 C₁₇H₂₀O₂ 
• 1381864-83-0 C₂₀H₂₆O₃ 
• 1381865-33-3 C₂₁H₂₆O₃ 
• 1424338-01-1 C₁₇H₁₈O₂ 
• 1424338-10-2 C₁₆H₁₆O₃ 
• 1202186-03-5 1-(2,5-dimethoxyphenyl)-1-phenyl-4-methyl-4-(tetrahydropyran-2-yloxy)-pent-2-yn-1-ol 
• 860402-63-7 4,7-dimethoxy-2,3-diphenyl-inden-1-one 

Relevant articles and documents

A palladium-catalyzed C-H functionalization route to ketones: Via the oxidative coupling of arenes with carbon monoxide

We describe the development of a new palladium-catalyzed method to generate ketones via the oxidative coupling of two arenes and CO. This transformation is catalyzed by simple palladium salts, and is postulated to proceed via the conversion of arenes into high energy aroyl triflate electrophiles. Exploiting the latter can also allow the synthesis of unsymmetrical ketones from two different arenes.

P -Selective (sp2)-C-H functionalization for an acylation/alkylation reaction using organic photoredox catalysis

p-Selective (sp2)-C-H functionalization of electron rich arenes has been achieved for acylation and alkylation reactions, respectively, with acyl/alkylselenides by organic photoredox catalysis involving an interesting mechanistic pathway.

An efficient and green method for regio- and chemo-selective Friedel-Crafts acylations using a deep eutectic solvent ([CholineCl][ZnCl2]3)

[CholineCl][ZnCl2]3, a deep eutectic solvent between choline chloride and ZnCl2, has been used as a dual function catalyst and green solvent for the Friedel-Crafts acylation of aromatic compounds instead of using the moisture-sensitive Lewis acids and volatile organic solvents. The reactions are performed with high yields under microwave irradiation with short reaction times for the synthesis of ketones. Interestingly, indole derivatives are regioselectively acylated in the 3-position under mild conditions with high yields without NH protection. Three new ketone products are synthesized. [CholineCl][ZnCl2]3 is easily synthesized from choline chloride and zinc chloride at a low cost, with easy purification and environmentally benign compounds. [CholineCl][ZnCl2]3 can be reused up to five times without loss of catalytic activity, making it ideal in industrial processes.