404034-84-0Relevant articles and documents
Palladium(0)-catalyzed coupling of organozinc iodide reagents with bromopyridines: Synthesis of selectively protected pyridine-containing azamacrocycles
Skerlj, Renato T.,Zhou, Yuanxi,Wilson, Trevor,Bridger, Gary J.
, p. 1407 - 1410 (2007/10/03)
The synthesis of azamacrocycles in which the ring nitrogens are regioselectively functionalized is described. An organozinc palladium(0)-catalyzed coupling with an appropriately functionalized bromopyridine generated a key intermediate, which was transformed in two steps to a desired precursor and subjected to an intramolecular N-alkylation to effect a macrocyclization affording selectively protected azamacrocycles 1-3.