405064-00-8

Basic information

• Product Name: Pyrimidine, 2-[[(4-methylphenyl)methyl]thio]-
• CAS NO: 405064-00-8
• Molecular Formula: C12H12N2S
• Molecular Weight: 216.307
• Mol File: 405064-00-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Pyrimidine, 2-[[(4-methylphenyl)methyl]thio]-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 2-[[(4-methylphenyl)methyl]thio]-(405064-00-8)
• EPA Substance Registry System: Pyrimidine, 2-[[(4-methylphenyl)methyl]thio]-(405064-00-8)

Safety Data

• Hazardous Substances Data: 405064-00-8(Hazardous Substances Data)

Upstream product

• 131242-36-9 2-sulfanylpyrimidine 
• 104-81-4 4-Methylbenzyl bromide 

Relevant articles and documents

Antimycobacterial Agents. 1. Thio Analogues of Purine

Thio analogues of purine, pyridine, and pyrimidine were prepared based on the initial activity screening of several analogues of these heterocycles against Mycobacterium tuberculosis (Mtb). Certain 6-thio-substituted purine analogues described herein showed moderate to good inhibitory activity. In particular, two purine analogues 9-(ethylcarboxymethyl)-6-(decylthio)-9H-purine (20) and 9-(ethylcarboxymethyl)-6-(dodecylthio)-9H-purine (21) exhibited MIC values of 1.56 and 0.78 μg/mL respectively against the Mtb H37Rv strain. N9-Substitution apparently enhances the antimycobacterial activity in the purine series described herein.