40949-94-8 Usage
Description
Potassium bis(trimethylsilyl)amide, also known as Potassium Hexamethyldisilazide, is a strong, sterically hindered base commonly used in organic synthesis. It is characterized by its ability to act as a nucleophile and a base, making it a versatile reagent for various chemical reactions.
Uses
Used in Organic Synthesis:
Potassium bis(trimethylsilyl)amide is used as a strong base for the alkylation of carbonyl compounds, facilitating the formation of new chemical bonds and enhancing the reactivity of the substrate.
Used in Enolate Generation:
In the pharmaceutical industry, Potassium bis(trimethylsilyl)amide is used as a sterically hindered base for enolate generation. This selective formation of linear conjugated dienolates and alkyl (Z)-3-alkenoates is crucial for the synthesis of complex organic molecules and the development of new drugs.
Used in Drug Synthesis:
Potassium bis(trimethylsilyl)amide (1M in THF) is utilized in the preparation of 5-azacytidine, an antineoplastic drug, as well as β3-AR agonists used in anti-stress formulations. Its application in these processes aids in the development of novel therapeutic agents for various medical conditions.
Used in Lanthanide Complex Preparation:
In the field of materials science, Potassium bis(trimethylsilyl)amide serves as a reagent in the preparation of lanthanide complexes. These complexes are employed in selective cyclization reactions, contributing to the advancement of materials with unique properties and potential applications in various industries.
Preparation
Potassium Hexamethyldisilazide is prepared and isolated by the procedure
of Wannagat and Niederpruem. A more convenient in situ
generation from potassium hydride and hexamethyldisilane is
described by Brown.
Check Digit Verification of cas no
The CAS Registry Mumber 40949-94-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,9,4 and 9 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 40949-94:
(7*4)+(6*0)+(5*9)+(4*4)+(3*9)+(2*9)+(1*4)=138
138 % 10 = 8
So 40949-94-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H18NSi2.K/c1-8(2,3)7-9(4,5)6;/h1-6H3;/q-1;+1