41446-22-4

Basic information

• Product Name: (S)-3-Benzyloxycarbonylamino-4-isobutoxycarbonyloxy-4-oxo-butyric acid tert-butyl ester
• Synonyms: (S)-3-Benzyloxycarbonylamino-4-isobutoxycarbonyloxy-4-oxo-butyric acid tert-butyl ester
• CAS NO: 41446-22-4
• Molecular Weight: 423.463
• Mol File: 41446-22-4.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: (S)-3-Benzyloxycarbonylamino-4-isobutoxycarbonyloxy-4-oxo-butyric acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-Benzyloxycarbonylamino-4-isobutoxycarbonyloxy-4-oxo-butyric acid tert-butyl ester(41446-22-4)
• EPA Substance Registry System: (S)-3-Benzyloxycarbonylamino-4-isobutoxycarbonyloxy-4-oxo-butyric acid tert-butyl ester(41446-22-4)

Safety Data

• Hazardous Substances Data: 41446-22-4(Hazardous Substances Data)

Upstream product

• 5545-52-8 Z-D(tBu)-OH 
• 63327-57-1 (2S), 2-benzyloxycarbonylamino-succinic acid 1-methyl ester 4-tertiobutyl ester 
• 543-27-1 isobutyl chloroformate 

Downstream Products

• 254751-09-2 (S)-tert-butyl 3-(((benzyloxy)carbonyl)amino)-4-oxo-5-(2,3,5,6-tetrafluoro phenoxy)pentanoate 
• 254751-10-5 (3S,4RS)-3-amino-5-(2',3',5',6'-tetrafluorophenoxy)-4-hydroxypentanoic acid tert-butyl ester 
• 1351767-67-3 C₂₆H₂₈F₂N₂O₆ 
• 1351767-66-2 C₂₅H₂₅F₃N₂O₅ 
• 1351767-65-1 C₂₅H₂₅BrF₂N₂O₅ 
• 1351767-64-0 C₂₅H₂₅ClF₂N₂O₅ 
• 1351767-75-3 C₂₆H₃₀F₂N₂O₆ 
• 1351767-74-2 C₂₅H₂₇F₃N₂O₅ 
• 1351767-73-1 C₂₅H₂₇BrF₂N₂O₅ 
• 1351767-72-0 C₂₅H₂₇ClF₂N₂O₅ 
• 1351767-63-9 C₂₆H₂₆F₄N₂O₆ 
• 1351767-62-8 C₂₅H₂₃F₅N₂O₅ 
• 1351767-61-7 C₂₅H₂₃BrF₄N₂O₅ 
• 1351767-60-6 C₂₅H₂₃ClF₄N₂O₅ 

Relevant articles and documents

Synthesis and evaluation of indole aspartyl ketones as novel caspase-3 inhibitors

Synthesis, biological evaluation and structure-activity relationships for a series of novel nonpeptide small molecule inhibitors of caspase-3 are described. Among the synthesized compounds, 2,3,5,6-tetrafluorophenoxymethyl ketone derivatives of indole-N-a

CASPASE INHIBITORS BASED ON PYRIDAZINONE SCAFFOLD

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N- and C-terminal modifications of negamycin

Negamycin 1 is a bactericidal antibiotic with activity against Gram-negative bacteria, and served as a template in an antibiotic discovery program. An orthogonally protected β-amino acid derivative 3a was synthesized and used in parallel synthesis of negamycin derivatives on solid support. This advanced intermediate was also used for N- and C-terminal modifications using solution-phase methodologies. The N-terminal modifications have resulted in the identification of active analogues, whereas the C-terminal modifications resulted in complete loss of antibacterial activity. The N-methyl negamycin analogue, 19a, inhibits protein synthesis (IC50=2.3 μM), has antibacterial activity (Escherichia coli, MIC=16 μg/mL), and is efficacious in an E. coli murine septicemia model (ED50=16.3 mg/kg).