4146-04-7

Basic information

• Product Name: D/L-NORVALINOL
• Synonyms: DL-2-AMINO-1-PENTANOL;D/L-NORVALINOL;2-AMINO-1-PENTANOL;2-AMINOPENTANOL;2-aminopentan-1-ol;2-azanylpentan-1-ol;DL-2-Amino-1-pentanol 97%
• CAS NO: 4146-04-7
• Molecular Formula: C₅H₁₃NO
• Molecular Weight: 103.16
• Product Categories: Amino Alcohols;Organic Building Blocks;Oxygen Compounds
• Mol File: 4146-04-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 29.84°C (estimate)
• Boiling Point: 194-195 °C(lit.)
• Flash Point: 203 °F
• Appearance: /
• Density: 0.922 g/mL at 25 °C(lit.)
• Vapor Pressure: 161mmHg at 25°C
• Refractive Index: n20/D 1.4511(lit.)
• CAS DataBase Reference: D/L-NORVALINOL(CAS DataBase Reference)
• NIST Chemistry Reference: D/L-NORVALINOL(4146-04-7)
• EPA Substance Registry System: D/L-NORVALINOL(4146-04-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• RIDADR: UN 2735 8/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 4146-04-7(Hazardous Substances Data)

Usage

Description

D/L-NORVALINOL, also known as DL-2-Amino-1-pentanol, is an organic compound with the molecular formula C5H12NO. It is a chiral molecule, which means it exists in two different forms, D and L, that are mirror images of each other. D/L-NORVALINOL is a colorless liquid at room temperature and is soluble in water.

Uses

Used in Pharmaceutical Industry:
D/L-NORVALINOL is used as a solvent for evaluating lyotropic liquid crystal mesophases of hexadecylpyridinium bromide (C16PyrBr) by cross-polarised optical microscopy (CPOM). This application is crucial in the development and analysis of drug delivery systems, as it helps researchers understand the behavior of these systems at the molecular level.
Used in Chemical Synthesis:
D/L-NORVALINOL can also be used as a starting material or intermediate in the synthesis of various pharmaceuticals and other chemicals. Its unique structure and functional groups make it a versatile building block for creating a wide range of compounds with different properties and applications.

InChI:InChI=1/C4H9N/c1-3-4-5-2/h3,5H,1,4H2,2H3

Upstream product

• 516-06-3 D,L-valine 
• 13893-43-1 ethyl 2-aminopentanoate 
• 132949-24-7 N-benzyloxy-1-((S)-2-methoxy-1-phenylethoxy)-4-penten-2-ylamine 
• 132949-27-0 1-((S)-2-Methoxy-1-phenyl-ethoxymethyl)-butylamine 
• 10047-10-6 norvaline methyl ester hydrochloride 
• 760-78-1 2-aminopentanoic acid 
• 2899-90-3 2-nitro-pentan-1-ol 

Downstream Products

• 16112-61-1 4-Propyl-oxazolidon-(2) 
• 69451-78-1 Nicotinic acid 2-[(pyridine-3-carbonyl)-amino]-pentyl ester 
• 137160-75-9 N-(1-Hydroxymethyl-butyl)-butyramide 
• 145842-46-2 (+/-)-2-(acetylamino)pentyl acetate 
• 4293-54-3 2-acetylaminopentan-1-ol 
• 189251-19-2 N-(p-toluenesulfonyl)-2-propylaziridine 
• 179684-02-7 2-(Boc-amino)-1-pentanol 
• 1617545-92-2 2-[6-(5-chloro-2-fluoro-phenyl)-pyrazin-2-ylamino]-pentan-1-ol 
• 22724-81-8 L-norvalinol 
• 80696-30-6 (2R)-2-aminopentan-1-ol 

Relevant articles and documents

A catalyst-free, convenient construction of eight-membered [1,4]oxazocane-5,8-dione heterocycles from aminoethanols with divinyl succinate

A convenient protocol for the synthesis of [1,4]oxazocane-5,8-dione heterocycles by direct cyclization using 2-substituted aminoethanols and divinyl succinate without any catalysts and additives was established. This strategy is quite simple and effective to obtain eight-membered rings incorporating lactone and lactam functional groups. Georg Thieme Verlag Stuttgart.

Enantioselective synthesis and absolute configuration of (-)-1-(benzofuran-2-yl)-2-propylaminopentane, ((-)-BPAP), a highly potent and selective catecholaminergic activity enhancer

Enantioselective synthesis and absolute configuration of (-)-1-(benzofuran-2-yl)-2-propylaminopentane ((-)-BPAP), which is a highly potent and selective catecholaminergic activity enhancer (CAE) substance, are described. The synthetic approach consists of the coupling reaction of benzofuran with (R)-N-tosyl-2-propylazirizine or (R)-N-methoxy-N-methylnorvaliamide, followed by appropriate modifications of the resulting coupling products. As the results, (-)-BPAP turned out to have the R configuration, which was finally confirmed by X-ray crystallographic analysis.

The use of alpha-amino acids in the synthesis of derivatives of 2-aminoethanethiol as potential antiradiation agents.

-