41994-44-9Relevant articles and documents
Covalent Occlusion of the RORγt Ligand Binding Pocket Allows Unambiguous Targeting of an Allosteric Site
Meijer, Femke A.,Van Den Oetelaar, Maxime C. M.,Doveston, Richard G.,Sampers, Ella N. R.,Brunsveld, Luc
, p. 631 - 639 (2021/04/07)
The nuclear receptor RORγt is a key positive regulator in the differentiation and proliferation of T helper 17 (Th17) cells and the production of proinflammatory cytokines like IL-17a. Dysregulation of this pathway can result in the development of various
METHOD FOR PRODUCING DICARBOXYLIC ACID COMPOUND
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Paragraph 0156; 0157, (2018/06/09)
It is an object of the present invention to provide an excellent method for producing an excellent therapeutic agent. The solution of the present invention is as shown in the following scheme: wherein R1 represents a C1-C6 alkyl group, R2 represents a C1-C6 alkyl group, and R3 represents a C1-C6 alkyl group.
NOVEL SULFONYLAMINOBENZAMIDE COMPOUNDS AS ANTHELMINTICS
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Page/Page column 25; 26, (2016/03/22)
The present invention relates to a new compound of formula (I) wherein the variables have the meaning as indicated in the claims; or an enantiomer or salt thereof. The compounds of formula (I) are useful in the control of parasites, in particular endopara