42471-28-3 Usage
Description
Nimustine, also known as ACNU, is an organochlorine compound that is a derivative of urea. It is characterized by the replacement of two hydrogens on one of the amino groups with nitroso and 2-chloroethyl groups, and one hydrogen from the other amino group with a 4-amino-2-methylpyrimidin-5-ylmethyl group. Nimustine is an antitumor agent that is particularly effective against malignant brain tumors.
Uses
Used in Oncology:
Nimustine is used as an antineoplastic agent for the treatment of malignant brain tumors. It works by inhibiting the synthesis of DNA and RNA, thereby preventing the growth and proliferation of cancer cells.
Used in Pharmaceutical Industry:
Nimustine is used in the pharmaceutical industry as a key ingredient in the development of drugs for the treatment of brain tumors and other types of cancer. Its unique chemical structure and mechanism of action make it a valuable component in the fight against cancer.
Originator
Nidran,Sankyo,Japan,1979
Manufacturing Process
0.4 g of sodium nitrite was added with stirring, at 0°C to 5°C, to a solution of
450 mg of 1-(2-chloroethyl)-3-[(2-methyl-4-aminopyridin-5-yl)methyl]urea in
8 ml of 5% hydrochloric acid, and the reaction mixture was then stirred at
0°C to 10°C for an additional 1.5 hours.After completion of the reaction, the reaction mixture was made alkaline by
the addition of sodium carbonate, whereupon crystals separated out in situ.
The crystals were recovered by filtration, washed with water and then
recrystallized from 6 ml of ethanol, to give 0.1 g of the pale yellow pure
desired product having a decomposition point of 125°C.
Therapeutic Function
Antitumor, Antileukemic
Check Digit Verification of cas no
The CAS Registry Mumber 42471-28-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,4,7 and 1 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 42471-28:
(7*4)+(6*2)+(5*4)+(4*7)+(3*1)+(2*2)+(1*8)=103
103 % 10 = 3
So 42471-28-3 is a valid CAS Registry Number.
InChI:InChI=1/C9H13ClN6O2.ClH/c1-6-12-4-7(8(11)14-6)5-13-9(17)16(15-18)3-2-10;/h4H,2-3,5H2,1H3,(H,13,17)(H2,11,12,14);1H
42471-28-3Relevant articles and documents
Concatamers for Immunemodulation
-
, (2012/04/23)
The invention relates to a polymeric, non-coding nucleic acid molecule for modulation of the activity of the human and animal immune system as well as a method for the manufacture thereof and a vaccine, comprising the polymeric, non-coding nucleic acid molecule, wherein polymeric, non-coding nucleic acid molecules may be understood as non-coding nucleic acid molecules, comprising at least four covalently bound molecules (tetramer) or are assemblies of more non-coding nucleic acid molecules (high molecular polymers) which are covalently bound to each other.