42498-32-8

Basic information

• Product Name: N-(tert-butyl)-4-methylbenzamide
• Synonyms: N-(tert-butyl)-4-methylbenzamide;N-(1,1-Dimethylethyl)-4-methylbenzamide
• CAS NO: 42498-32-8
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 191.27
• Mol File: 42498-32-8.mol
• Article Data: 57

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-(tert-butyl)-4-methylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(tert-butyl)-4-methylbenzamide(42498-32-8)
• EPA Substance Registry System: N-(tert-butyl)-4-methylbenzamide(42498-32-8)

Safety Data

• Hazardous Substances Data: 42498-32-8(Hazardous Substances Data)

Usage

General Description

N-(tert-butyl)-4-methylbenzamide is a chemical compound with the molecular formula C12H17NO. It is a white to off-white solid with a molecular weight of 191.27 g/mol. N-(tert-butyl)-4-methylbenzamide is commonly used in the synthesis of various pharmaceuticals, agrochemicals, and materials. It is also used as an intermediate in the production of organic compounds and as a reagent in chemical reactions. N-(tert-butyl)-4-methylbenzamide is known to have low toxicity and is not considered to be a significant environmental or health hazard. However, it should be handled with care and in accordance with proper safety protocols.

Upstream product

• 130407-67-9 N-tert-butyltoluamidine hydrochloride 
• 874-60-2 4-methyl-benzoyl chloride 
• 75-64-9 tert-butylamine 
• 6852-60-4 N-tert-butyl-2-methylpropanimine 
• 201230-82-2 carbon monoxide 
• 106-45-6 para-thiocresol 
• 540-88-5 acetic acid tert-butyl ester 
• 104-85-8 para-methylbenzonitrile 
• 106-38-7 para-bromotoluene 
• 86401-98-1 tert-butyl-(4-methylbenzilidene)amine 
• 17177-63-8 4-tolyl mesylate 
• 13939-06-5 molybdenum hexacarbonyl 
• 75-65-0 tert-butyl alcohol 
• 119072-55-8 tert-butylisonitrile 

Downstream Products

• 99-94-5 p-Toluic acid 
• 75-64-9 tert-butylamine 
• 162330-18-9 4-(bromomethyl)-N-(tert-butyl)benzamide 
• 162329-95-5 (E)-N-tert-butyl-4-<2-(1,2-dihydro-1-methyl-2-oxopyridine-5-yl)ethenyl>benzamide 
• 162329-96-6 (E)-N-tert-butyl-4-<2-(1,2-dihydro-1-methyl-2-oxopyridine-5-yl)-2-methylethenyl>benzamide 
• 100654-62-4 (C₆H₄(CH₃)C(O)NH(C(CH₃)3))2VCl₄ 
• 100654-50-0 (C₆H₄(CH₃)C(O)NH(C(CH₃)3))2SnCl₄ 
• 100654-67-9 (C₆H₄(CH₃)C(O)NH(C(CH₃)3))SbCl₅ 
• 100654-55-5 (C₆H₄(CH₃)C(O)NH(C(CH₃)3))2SnBr₄ 
• 104-85-8 para-methylbenzonitrile 
• 1404220-15-0 N-tert-butyl-4-methyl-2-(4-nitrophenylamino)benzamide 
• 1450753-64-6 N-tert-butyl-4-methyl-2-(4-nitrobenzamido)benzamide 

Relevant articles and documents

Weak base-promoted selective rearrangement of oxaziridines to amidesviavisible-light photoredox catalysis

The selective rearrangement of oxaziridines to amidesviaa single electron transfer (SET) pathway is unexplored. In this study, we present a weak base-promoted selective rearrangement of oxaziridines to amidesviavisible-light photoredox catalysis. The developed method shows excellent functional group tolerance with a broad substrate scope and good to excellent yields. Furthermore, control experiments and density functional theory (DFT) calculations are performed to gain insight into the reactivity and selectivity.

Nickel-catalyzed aminocarbonylation of Aryl/Alkenyl/Allyl (pseudo)halides with isocyanides and H2O

Herein described is a nickel-catalyzed aminocarbonylation of aryl/alkenyl/allyl (pseudo)halides with isocyanides, providing aryl/alkenyl/allyl amides in 41% to 92% yields. Functional groups such as F, Cl, OMe, and heteroaromatic rings are compatible in the reaction. A Ni(0)/Ni(II) catalytic cycle is proposed based on preliminary experiments and previous literature. The reaction features readily available nickel salt, broad functional group tolerance, and simple reaction conditions.

Chemoselective formation of C–N bond in wet acetonitrile using amberlyst-15(H) as a recyclable catalyst

An economically efficient and environmentally benign protocol for the chemoselective one-pot synthesis of diversely N-substituted amides has been developed in good yield through the reaction of benzylic secondary alcohols as well as aliphatic tertiary alcohols and alkyl/aryl nitriles. Commercially available Amberlyst-15(H) has been utilized at 80 °C as an air-stable and reusable heterogeneous inexpensive solid acid catalyst without any anhydrous and inert environment. The attractive features of the present synthetic protocol are mild reaction conditions, short reaction time, excellent chemoselectivity, high atom economy and tolerance of various sensitive moieties.