425403-78-7

Basic information

• Product Name: (S)-4-[(S)-2-(2'-Methoxy-biphenyl-4-yl)-1-methoxycarbonyl-ethylcarbamoyl]-thiazolidine-3-carboxylic acid tert-butyl ester
• CAS NO: 425403-78-7
• Molecular Weight: 500.616
• Mol File: 425403-78-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-4-[(S)-2-(2'-Methoxy-biphenyl-4-yl)-1-methoxycarbonyl-ethylcarbamoyl]-thiazolidine-3-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-[(S)-2-(2'-Methoxy-biphenyl-4-yl)-1-methoxycarbonyl-ethylcarbamoyl]-thiazolidine-3-carboxylic acid tert-butyl ester(425403-78-7)
• EPA Substance Registry System: (S)-4-[(S)-2-(2'-Methoxy-biphenyl-4-yl)-1-methoxycarbonyl-ethylcarbamoyl]-thiazolidine-3-carboxylic acid tert-butyl ester(425403-78-7)

Safety Data

• Hazardous Substances Data: 425403-78-7(Hazardous Substances Data)

Upstream product

• 63091-82-7 (S)-3-(tert-butoxycarbonyl)thiazolidine-4-carboxylic acid 
• 153037-35-5 (S)-2-amino-3-(2'-methoxybiphenyl-4-yl)propionic acid methyl ester 

Relevant articles and documents

Specific and dual antagonists of α4β1 and α4β7 integrins

N-(3,5-Dichlorophenylsulfonyl)-(R)-thioprolyl biarylalanine 10a has been identified as a potent and specific antagonist of the α4β1 integrin. Altering the configuration of thioproline from R to S led to a series of dual antagonists of α4β1 and α4β7, and the N-acetyl analogue 8b was found to be the most potent dual antagonist. A binding site model for α4β1 and α4β7 is proposed to explain the structure-activity relationship.