432-87-1

Basic information

• Product Name: 4-(TRIFLUOROMETHYLSULFONYL)NITROBENZENE
• Synonyms: 4-(trifluoromethylsulfonyl)-1-nitrobenzene;trifluoromethylsulfonylnitrobenzene;4-(TRIFLUOROMETHYLSULFONYL)NITROBENZENE
• CAS NO: 432-87-1
• Molecular Formula: C₇H₄F₃NO₄S
• Molecular Weight: 255.17
• Mol File: 432-87-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(TRIFLUOROMETHYLSULFONYL)NITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(TRIFLUOROMETHYLSULFONYL)NITROBENZENE(432-87-1)
• EPA Substance Registry System: 4-(TRIFLUOROMETHYLSULFONYL)NITROBENZENE(432-87-1)

Safety Data

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 432-87-1(Hazardous Substances Data)

Usage

Description

4-(TRIFLUOROMETHYLSULFONYL)NITROBENZENE, with the molecular formula C7H4F3NO4S, is a nitrobenzene derivative featuring a trifluoromethylsulfonyl group. This yellow solid at room temperature is insoluble in water and is recognized for its potential toxicity, necessitating careful handling and storage in well-ventilated areas to prevent skin, eye, and respiratory irritation.

Uses

Used in Organic Synthesis:
4-(TRIFLUOROMETHYLSULFONYL)NITROBENZENE serves as a valuable building block in organic synthesis, contributing to the creation of various complex organic compounds due to its unique chemical structure.
Used in Pharmaceutical Manufacturing:
In the pharmaceutical industry, 4-(TRIFLUOROMETHYLSULFONYL)NITROBENZENE is utilized as a reagent, playing a crucial role in the development and production of diverse medications.
Used in Agrochemical Production:
4-(TRIFLUOROMETHYLSULFONYL)NITROBENZENE also finds application in agrochemical manufacturing, where it is employed as a reagent to help produce chemicals used in agricultural applications for pest control and crop protection.

Upstream product

• 403-66-7 p-nitrophenyl trifluoromethyl sulfide 
• 84796-68-9 C₇H₄F₃N₃O₄S 
• 456-56-4 phenyl trifluoromethylsulfide 
• 6325-93-5 p-nitrobenzenesulfonamide 
• 636-98-6 p-nitrobenzene iodide 
• 713-66-6 4-nitrophenyl trichloromethylsulfide 
• 905718-45-8 [(4-nitrophenyl)(phenyl)iodonium trifluoromethanesulfonate] 
• 2926-29-6 Langlois reagent 
• 1310070-02-0 (4-methoxyphenyl)(4-nitrophenyl)iodonium p-toluenesulfonate 
• 100-01-6 4-nitro-aniline 
• 1146127-11-8 (4-nitrophenyl)(2,4,6-trimethylphenyl)iodonium trifluoromethanesulfonate 
• 1961266-44-3 2,8-difluoro-5-(trifluoromethyl)-5H-dibenzo[b,d]thiophen-5-ium trifluoromethanesulfonate 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 

Downstream Products

• 473-27-8 4-(trifluoromethanesulfonyl)aniline 
• 944-30-9 p-fluorophenyl trifluoromethyl sulfone 
• 432-84-8 4-Hydroxyphenyltrifluoromethylsulphone 
• 402-54-0 p-nitrobenzotrifluoride 
• 2143-88-6 4-nitro-4'-methyl-1,1'-biphenyl 
• 677008-29-6 C₁₂⁽¹¹⁾CH₉NO₃ 
• 312-20-9 1-bromo-4-(trifluoromethylsulfonyl)benzene 
• 325-83-7 Trifluormethyl-<2-amino-benzthiazol-(6)-yl>-sulfon 
• 360-01-0 1-iodo-4-((trifluoromethyl)sulfonyl)benzene 

Relevant articles and documents

Practical and efficient synthesis of aryl trifluoromethyl sulfones from arylsulfonyl chlorides with Umemoto's reagent II

A practical and efficient method for the synthesis of aryl trifluoromethyl sulfones has been developed by a tandem reaction of arylsulfonyl chlorides with Umemoto's reagent II. The advantageous features of this method are simple operation, mild reaction conditions, wide scope of substrates, high yield of products, and easy scalability.

Copper-Promoted Trifluoromethanesulfonylation and Trifluoromethylation of Arenediazonium Tetrafluoroborates with NaSO2CF3

A tunable chemoselective trifluoromethanesulfonylation and trifluoromethylation of arenediazonium tetrafluoroborates with Langlois' reagent (NaSO2CF3) was developed. The Cu2O-catalyzed reaction in DMSO gave aryl trifluoromethanesulfones as the major products. On the other hand, the trifluoromethylated arenes were produced in the presence of oxidant tert-butyl hydroperoxide, CuBF4(MeCN)4, and 2,2′;6′,2 terpyridine (tpy). Both of these transformations proceed under mild conditions and tolerate functional groups.

Convenient one-pot procedure for converting aryl sulfides to nitroaryl sulfones

When treated with nitrogen dioxide and ozone in inert solvent at 0°C or below, aryl sulfides underwent smooth oxidative nitration to give nitroaryl sulfones in good yield. Using this methodology, a series of mono- and di-nitrated aryl sulfones were prepared from methyl phenyl sulfide and diphenyl sulfide and their physical data are presented.