4363-93-3Relevant articles and documents
Synthesis of cinchoninic acid, quininic acid and of the corresponding aldehydes
Schultz,Amschler
, p. 192 - 195 (1970)
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Synthetic approaches to Cinchona alkaloids: The C-8/C-9 disconnection strategy
Jankowski, Rapha?l,Joseph, Delphine,Cavé, Christian,Dumas, Fran?oise,Ourevitch, Michèle,Mahuteau, Jacqueline,Morgant, Georges,Pavlovi?, Nada Bosnjakovi?,D'Angelo, Jean
, p. 4187 - 4190 (2003)
When conducted in DMSO, the Hünig's base-promoted condensation of 3-quinuclidinone with quinoline-4-carboxaldehyde gave an equimolar mixture of epimeric aldols 8 with an excellent yield.
Hydroxymethylation of quinolinesviairon promoted oxidative C-H functionalization: synthesis of arsindoline-A and its derivatives
Shantharjun, Bangarigalla,Vani, Damera,Unnava, Ramanjaneyulu,Sandeep, Mummadi,Reddy, Kallu Rajender
, p. 645 - 652 (2021/02/06)
Herein, we report a mild and efficient hydroxymethylation of quinolinesviaan iron promoted cross-dehydrogenative coupling reaction under external acid free conditions. Various hydroxyalkyl substituted quinolines were achieved in excellent yields with well tolerated functional groups. Importantly, a few of the hydroxylmethylated quinolines were further transformed into respective aldehydes, and were successfully utilized for the synthesis of alkaloid arsindoline-A and its derivatives.
Iodine-imine Synergistic Promoted Povarov-Type Multicomponent Reaction for the Synthesis of 2,2′-Biquinolines and Their Application to a Copper/Ligand Catalytic System
Hu, Qi-Qi,Gao, Yan-Ting,Sun, Jia-Chen,Gao, Jing-Jing,Mu, Hong-Xiao,Li, Yi-Ming,Zheng, Ya-Nan,Yang, Kai-Rui,Zhu, Yan-Ping
supporting information, p. 9000 - 9005 (2021/11/24)
An efficient iodine-imine synergistic promoted Povarov-type multicomponent reaction was reported for the synthesis of a practical 2,2′-biquinoline scaffold. The tandem annulation has reconciled iodination, Kornblum oxidation, and Povarov aromatization, where the methyl group of the methyl azaarenes represents uniquely reactive input in the Povarov reaction. This method has broad substrate scope and mild conditions. Furthermore, these 2,2′-biquinoline derivatives had been directly used as bidentate ligands in metal-catalyzed reactions.