4402-22-6

Basic information

• Product Name: 1,2-Bis(4-nitrobenzoyl)hydrazine
• Synonyms: 1,2-Bis(4-nitrobenzoyl)hydrazine;4-nitro-N'-(4-nitrobenzoyl)benzohydrazide (non-preferred name)
• CAS NO: 4402-22-6
• Molecular Formula: C₁₄H₁₀N₄O₆
• Molecular Weight: 330.2524
• Mol File: 4402-22-6.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 670.1°Cat760mmHg
• Flash Point: 359.1°C
• Appearance: /
• Density: 1.489g/cm³
• CAS DataBase Reference: 1,2-Bis(4-nitrobenzoyl)hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Bis(4-nitrobenzoyl)hydrazine(4402-22-6)
• EPA Substance Registry System: 1,2-Bis(4-nitrobenzoyl)hydrazine(4402-22-6)

Safety Data

• Hazardous Substances Data: 4402-22-6(Hazardous Substances Data)

Usage

Description

1,2-Bis(4-nitrobenzoyl)hydrazine is a hydrazine derivative featuring two 4-nitrobenzoyl groups attached to the nitrogen atom. It is a chemical compound widely utilized in the synthesis of organic compounds and pharmaceuticals. Known for its potent nucleophilic properties, it serves as a valuable reagent in the chemical industry. Furthermore, it is employed in the production of fluorescent dyes and as a building block in the synthesis of various heterocyclic compounds. Its demonstrated biological activity also positions it as an important target for drug discovery and development.

Uses

Used in Chemical Synthesis:
1,2-Bis(4-nitrobenzoyl)hydrazine is used as a reagent in the chemical industry for its powerful nucleophilic properties, facilitating the synthesis of a variety of organic compounds and pharmaceuticals.
Used in Pharmaceutical Production:
As a key intermediate in the synthesis of pharmaceuticals, 1,2-Bis(4-nitrobenzoyl)hydrazine contributes to the development of new drugs and medicines.
Used in Fluorescent Dye Production:
1,2-Bis(4-nitrobenzoyl)hydrazine is used as a building block in the production of fluorescent dyes, which have applications in various fields such as bioimaging and diagnostics.
Used in Heterocyclic Compound Synthesis:
1,2-Bis(4-nitrobenzoyl)hydrazine is utilized in the synthesis of heterocyclic compounds, which are important in the creation of complex organic molecules and pharmaceuticals.
Used in Drug Discovery and Development:
Due to its demonstrated biological activity, 1,2-Bis(4-nitrobenzoyl)hydrazine is an important target for further research in drug discovery and development, potentially leading to the creation of new therapeutic agents.

Upstream product

• 110-86-1 pyridine 
• 122-04-3 4-nitro-benzoyl chloride 
• 79-19-6 thiosemicarbazide 
• 76328-74-0 3-(4-nitro-benzoylhydrazono)-butyric acid ethyl ester 
• 28078-88-8 4-nitrobenzoic acid pentafluorophenyl ester 
• 636-97-5 N-amino-(4-nitrophenyl)carboxamide 
• 7803-57-8 hydrazine hydrate 
• 71-43-2 benzene 
• 127-09-3 sodium acetate 
• 62-23-7 4-nitro-benzoic acid 
• 4231-71-4 1H-1,2,3-benzotriazol-1-yl-4-nitrophenylmethanone 
• 619-50-1 4-nitrobenzoic acid methyl ester 
• 33288-81-2 N,N'-(ethane?1,2?diyl)bis(4?nitrobenzamide) 
• 75-05-8 acetonitrile 

Downstream Products

• 50975-53-6 p-amino-N'-(p-aminobenzoyl)benzohydrazide 
• 1044-49-1 bis-(4-nitro-phenyl)-[1,3,4]oxadiazole 
• 88203-21-8 2, 5-bis(4-nitrophenyl)-1,3,4-thiadiazole 
• 1090-82-0 2-(4-nitrophenyl)-5-phenyl-1,3,4-oxadiazole 
• 2642-62-8 4,4'-(1,3,4-thiadiazole-2, 5-diyl)dianiline 
• 51725-77-0 3,5-bis-(4-nitro-phenyl)-1H-[1,2,4]triazole 
• 5286-77-1 3,5-bis-(4-nitro-phenyl)-4-phenyl-4H-[1,2,4]triazole 
• 92061-22-8 2-(4-aminophenyl)-5-(4-nitrophenyl)-1,3,4-oxadiazole 
• 37932-42-6 3,6-bis(4-nitrophenyl)-1,2,4,5-tetrazine 
• 53876-69-0 3,6-bis-(4-nitro-phenyl)-1,2-dihydro-[1,2,4,5]tetrazine 

Relevant articles and documents

Optical detection of sodium salts of fluoride, acetate and phosphate by a diacylhydrazine ligand by the formation of a colour alkali metal complex

A solution of N, N'-diacylhydrazine ligand in organic solvent is potential for colourimetric detection of F-/AcO-/PO 3-4 via -NH deprotonation, tautomerization and its stabilization as a colour alkali metal comp

Hypochlorite responsive even hydrazide connecting key and application thereof

The invention discloses a hypochlorite responsive even hydrazide connecting key and application thereof. A structural formula of the connecting key is (with the reference to the specification); the connecting key is prepared from an R1 parent containing reactive carbonyl and an R2 parent containing reactive carbonyl by a reaction with hydrazine hydrate; the reactive carbonyl can be ester, carboxylic acid, acyl chloride, aldehyde or cyclic ketone. The connecting key can react with specificity of OCl, is oxidized and cut off by OCl to form carboxyl so as to distinguish OCl in ROS, has high specificity, and can be widely used in various fields of hypochlorite response, such as a hypochlorite fluorescent probe, a hypochlorite responsive drug carrier, a hypochlorite responsive nano probe, a prodrug for treating ROS related diseases, a carrier with double effects of diagnosis and treatment and the like.

Flexible and highly fluorescent aromatic polyimide: design, synthesis, properties, and mechanism

To develop high-performance flexible fluorescent aromatic polyimides and to have a deeper insight into the fluorescence mechanism, two diamine monomers PyDA and TzDA with similar chemical structures but totally different electronic effects, were designed and synthesized. PyDA bears an electron-donor pyrrole group while TzDA bears an electron-acceptor 1,2,4-triazole group. The resulting aromatic polyimide TzODPI containing the triazole group showed bright green photoluminescence with a high quantum yield of up to 61% in solution and 13% in the film state. However, fluorescence was totally quenched in the pyrrole-containing polyimide PyODPI. The completely different phenomena were systematically elucidated with the aid of molecular simulations. Theoretical calculations for the molecular orbital distribution, oscillator strength, and the electron transition process between the ground state and excited state of model molecules were applied to clarify the fluorescence mechanism. Highly fluorescent aromatic polyimides can be obtained by appropriate control of the intra-molecular charge-transfer effects between the diamine and dianhydride moieties, and this demonstrates a simple strategy to develop wholly aromatic polyimides with high fluorescence for potential applications in the field of flexible displays.