441773-67-7

Basic information

• Product Name: (Z)-tert-butyl 3-(2-Methoxy-2-oxoethylidene)pyrrolidine-1-carboxylate
• Synonyms: (Z)-tert-butyl 3-(2-Methoxy-2-oxoethylidene)pyrrolidine-1-carboxylate;tert-butyl 3-(2-methoxy-2-oxoethylidene)pyrrolidine-1-carboxylate
• CAS NO: 441773-67-7
• Molecular Formula: C₁₂H₁₉NO₄
• Molecular Weight: 241.28356
• Mol File: 441773-67-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (Z)-tert-butyl 3-(2-Methoxy-2-oxoethylidene)pyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-tert-butyl 3-(2-Methoxy-2-oxoethylidene)pyrrolidine-1-carboxylate(441773-67-7)
• EPA Substance Registry System: (Z)-tert-butyl 3-(2-Methoxy-2-oxoethylidene)pyrrolidine-1-carboxylate(441773-67-7)

Safety Data

• Hazardous Substances Data: 441773-67-7(Hazardous Substances Data)

Usage

General Description

(Z)-tert-butyl 3-(2-Methoxy-2-oxoethylidene)pyrrolidine-1-carboxylate is a chemical compound that belongs to the class of pyrrolidine carboxylates. It is a derivative of pyrrolidine and contains a tert-butyl group as well as a methoxy and oxoethylidene functional group. (Z)-tert-butyl 3-(2-Methoxy-2-oxoethylidene)pyrrolidine-1-carboxylate has potential applications in the pharmaceutical and agrochemical industries due to its unique structure and properties. However, its specific uses and properties would depend on further research and testing.

Upstream product

• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 101385-93-7 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 5927-18-4 trimethyl phosphonoacetate 

Downstream Products

• 441773-73-5 3-ethoxycarbonylmethyl-3-(4-hydroxy-phenylsulfanylmethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 441773-68-8 3-(2-hydroxy-ethylidene)-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Preparation method of R-N-Boc-3-pyrrolidine acetic acid

The invention provides a preparation method of R-N-Boc-3-pyrrolidine acetic acid, which comprises the following steps: by using N-Boc-3-pyrrolidone and trimethyl phosphonyl acetate as raw materials, carrying out wittig reaction, asymmetric reduction hydrogenation reaction and hydrolysis reaction to obtain the R-N-Boc-3-pyrrolidine acetic acid. The preparation method starts from a low-price racemicmixture N-Boc-3-pyrrolidone, the reaction conditions are mild, use of dangerous materials is not needed, the reaction steps are few, the process is simple, the single product R-N-Boc-3-pyrrolidine acetic acid with a target chiral structure can be finally obtained, the product has high purity, an optical activity ee value of more than 99% and high yield, and industrial scale-up production is facilitated.

Synthesis and structure-activity relationship of a novel sulfone series of TNF-α converting enzyme inhibitors

Replacement of the amide functionality in IM491 (N-hydroxy-(5S,6S)-1- methyl-6-{[4-(2-methyl-4-quinolinylmethoxy)anilinyl]carbonyl} -5-piperidinecarboxamide) with a sulfonyl group led to a new series of α,β-cyclic and β,β-cyclic γ-sulfonyl hydroxamic acids, which were potent TNF-α converting enzyme (TACE) inhibitors. Among them, inhibitor 4b (N-hydroxy-(4S,5S)-1-methyl-5-{[4-(2-methyl-4- quinolinylmethoxy)phenyl]sulfonylmethyl}-4-pyrrolidinecarboxamide) exhibited IC50 values of 1 nM and 180 nM in porcine TACE (pTACE) and cell assays, respectively, with excellent selectivity over MMP-1, -2, -9 and -13 and was orally bioavailable with an F value of 46% in mice.