4465-65-0 Usage
Description
4-EPI-ANHYDROTETRACYCLINE HYDROCHLORIDE, also known as Epianhydrotetracycline, is a secondary degradation product derived from Tetracycline, an antibiotic. It is formed by epimerisation of tetracycline and dehydration at the C6 position, leading to the aromatisation of the B ring. This chemical process results in an orange powder with unique properties. Although it has a reduced antibiotic activity compared to its parent compound, it is still considered biologically active and is thought to contribute to the toxicity of Tetracycline.
Uses
Used in Pharmaceutical Industry:
4-EPI-ANHYDROTETRACYCLINE HYDROCHLORIDE is used as a pharmaceutical compound for its potential contribution to the toxicity of Tetracycline. Studies have shown that this derivative can have a 250-fold higher toxicity depending on the system under study. This characteristic makes it a valuable compound for further research and development in the pharmaceutical industry, particularly in the context of antibiotic resistance and the need for new or modified antibiotics.
Used in Quality Control and Stability Monitoring:
In the pharmaceutical and biotechnology industries, 4-EPI-ANHYDROTETRACYCLINE HYDROCHLORIDE is used as an important standard for monitoring the stability of Tetracycline. The degradation of Tetracycline to this compound is associated with a loss of antibiotic activity, making it a crucial indicator of the drug's shelf life and efficacy. By monitoring the levels of Epianhydrotetracycline, manufacturers can ensure the quality and safety of Tetracycline-based products.
Used in Research and Development:
4-EPI-ANHYDROTETRACYCLINE HYDROCHLORIDE is used as a research compound for studying the biological activity and toxicity of Tetracycline and its derivatives. This knowledge can be applied to the development of new antibiotics or the modification of existing ones to improve their efficacy and safety profile. Additionally, understanding the mechanisms behind the toxicity of this compound can help in the design of safer and more effective pharmaceuticals.
Used in Environmental Monitoring:
Due to its biological activity and potential contribution to the toxicity of Tetracycline, 4-EPI-ANHYDROTETRACYCLINE HYDROCHLORIDE can be used in environmental monitoring to assess the presence and impact of Tetracycline residues in the environment. This is particularly relevant in the context of antibiotic pollution in water bodies and soil, where the degradation of Tetracycline can lead to the formation of this compound and other degradation products with potential ecological consequences.
Check Digit Verification of cas no
The CAS Registry Mumber 4465-65-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,4,6 and 5 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 4465-65:
(6*4)+(5*4)+(4*6)+(3*5)+(2*6)+(1*5)=100
100 % 10 = 0
So 4465-65-0 is a valid CAS Registry Number.
InChI:InChI=1/C22H22N2O7/c1-8-9-5-4-6-12(25)13(9)17(26)14-10(8)7-11-16(24(2)3)18(27)15(21(23)30)20(29)22(11,31)19(14)28/h4-6,11,16,25-26,30-31H,7,23H2,1-3H3/p+1/t11-,16+,22-/m0/s1
